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Diss Factsheets
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EC number: 273-868-3 | CAS number: 69103-01-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Two key studies have been used in a weight-of-evidence approach:
In a study carried out according to OECD 301 F and GLP (Kreutzer, 2010), Neobergamate forte biodegraded 44% biodegradation after 28 days and 61% after 60 days.
In a study carried out according to OECD 301 B and GLP (King, 1996), Neobergamate forte biodegraded 59% biodegradation after 28 days.
According to both tests, the substance should be regarded as not readily biodegradable but as inherently biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- inherently biodegradable
Additional information
The ready biodegradability of Neobergamate Forte has been investigated using two standard ready screening methods, the OECD 301F Manometric Respirometry Test (Kreutzer 2010) and a modified OEC301B test in sealed vessels (King 1996). The average level of biodegradation achieved after 28 days was 44% and 59 % respectively. Therefore, Neobergamate Forte cannot be regarded as readily biodegradable.
The slower rate of biodegradation observed in the OECD 301F test compared to the sealed OECD 301B test is likely attributed to the higher test concentration used (100mg/L compared to 10 mg/L).
The result from the modified 301B sealed test of 59% is only just below the pass level criterion of 60%. Such results can be used to prove inherent biodegradability (ECHA Guidance, Chapter R.7b, Version 2.0 - November 2014, p197). This is also the case when the pass level criterion is fulfilled in an extended ready biodegradability test. The OECD 301F test was prolonged beyond 28 days because the curve showed that a plateau had not been reached. The level of degradation achieved after 60 days was 61%. Therefore, Neobergamate Forte should be regarded as inherently biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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