Registration Dossier
Registration Dossier
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EC number: 201-557-4 | CAS number: 84-74-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Test animals
- Species:
- rabbit
Results and discussion
Any other information on results incl. tables
A study in rabbits with undiluted DBP (OECD Guideline 404) revealed slight erythema in 2 out of 3 animals immediately after exposure and after 24 hours. No oedema was seen. Erythema disappeared 48 hours after exposure. DBP was not considered a skin irritant (BASF 1990a*).
Greenough et al. (1981*) reported mild reactions 24 hours after 0.5 mL of undiluted Vestinol C (DBP trade name) was applied to intact and abraded rabbit skins. The positive control was reported as 10 % laurylsulphate. No reaction was observed after 72 hours at any treatment site. The irritation index was calculated as 0.54/8.
A study cited in an NTP-CERHR report on DBP (CERHR 2003) reported minor irritation in rabbit dermal occlusion studies at 520 mg/kg bw/d.
Applicant's summary and conclusion
- Conclusions:
- These studies suggest that DBP causes minimal skin irritation in rabbits.
- Executive summary:
Sligth skin irritation was reported, which dissappeared after 48h (study 1) or 72h (study 2).
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