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Diss Factsheets
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EC number: 235-845-6 | CAS number: 13005-36-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Review
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of Phenylacetic Acid
- Author:
- Sherwin CP & Kennard KS
- Year:
- 1 919
- Bibliographic source:
- j.biol.chem.40:259
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenylacetic acid
- EC Number:
- 203-148-6
- EC Name:
- Phenylacetic acid
- Cas Number:
- 103-82-2
- IUPAC Name:
- phenylacetic acid
- Details on test material:
- No data
Constituent 1
Results and discussion
Any other information on results incl. tables
A hen weighing 2.23 kilos, after receiving 1 gm of the aid, refused to eat. A second dose of 1 gm 3 days later caused the hen to lose wight and develop marked signs of intoxication.
A dog weighing 32.6 kilos was able to take 3gm of the acid with no apparent signs of discomfort; however, after receiving a dose of 7 gm of the acid it became very thirsty, refused to eat, seemed to be greatly nauseated, and vomited several times.
A monkey of 4.2 kilos body weight, which recieved a dose of 1gm and refused to eat for several days, also developed a marked diarrhea.
Twelve adult humans (male) after ingesting 5 gm each of the acid showed in every case practically the same symptoms. The sodium salt of the acid was dissolved in 200 to 300 cc of water and rapidly drunk. In 15 to 30 minutes after the ingestion of the acid, the subject became thirsty and this symptom was rapidly followed by a feeling of hunger. If food was ingested, symptoms of nausea developed; in case no food was taken, a feeling of dizziness resulted, followed either by drowsiness or increased nervousness.
One subject weighing 59.1 kilos ingested as much as 16 gm of the acid within a period of 2 hours. Within a few minutes, the usual sensation of dizziness and hunger developed, so the subject partook of an unusually heavy meal and went to bed. One hour after ingesting the last of the acid, he was unable even to stand unsupported. After sleeping soundly for 6 hours, he awoke and drank one liter of water, immediately fell asleep, and again slept soundly for 8 hours. On waking he demanded water and drank more than one and a half liters. He complained of nausea, headache, pain in the eye, and of loud rining in the ears. He was able to sit alone but seemed unable to stand unsupported or to correlate his movement. After another 4 hours of sleep, he appeared quite refreshed and normal in every way. In this case there was no sign of diarrhea but on the contrary he presented an obstinate case of constipation, which lasted for about 3 weeks. In many respect the symptoms of poisoning by this acid resemble those of alcoholic poisoning.
Applicant's summary and conclusion
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