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EC number: 209-886-5 | CAS number: 596-49-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Biodegradation in water: screening tests
Predicted data for the test compoundBenzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)-(CAS No. 596-49-6) and the study for its read across substance were reviewed for the biodegradation end point which are summarized as below:
Estimation Programs Interface Suite (EPI suite, 2016) was run to predict the biodegradation potential of the test compound Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS no. 596 -49 -6) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI LInear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that Benzenemethanol, 4-(diethylamino)-alpha, alpha-bis (4-(diethylamino ) phenyl)- is not expected to be readily biodegradable.
28-days Manometric respirometry test following the OECD guideline 301F to determine the ready biodegradability of the read across chemical Hydrogen [4-[4-(diethylamino)-2', 4'-disulphonatobenzhydrylidene] cyclohexa-2, 5-dien-1-ylidene] diethylammonium, sodium salt (CAS No. 129-17-9) (UERL study report,Sustainability Support Services (Europe) AB, Report no.129-17-9/02/2015/RBD, 2016). The test system included control, test item and reference item. The concentration of read across chemical and reference item (Sodium Benzoate) chosen for both the study was 100mg/L, while that of inoculum was 10ml/l. ThOD (Theoretical oxygen demand) of test and reference item was determined by calculation. % Degradation was calculated using the values of BOD and ThOD for read across substance and reference item.
The BOD28value of Hydrogen [4-[4-(diethylamino)-2', 4'-disulphonatobenzhydrylidene] cyclohexa-2, 5-dien-1-ylidene] diethylammonium, sodium salt (CAS No. 129-17-9) was observed to be 0.0335 mgO2/mg. ThOD was calculated as 1.892 mgO2/mg. Accordingly, the % degradation of read across substance after 28 days of incubation at 20 ± 1°C according to manometric respirometry test was determined to be 1.77%.Based on the results, Hydrogen [4-[4-(diethylamino)-2', 4'-disulphonatobenzhydrylidene] cyclohexa-2, 5-dien-1-ylidene] diethylammonium, sodium salt, under the test conditions, was determined to be non-biodegradable at 20 ± 1°C over a period of 28 days.
Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of read across substance CI acid violet 49 (CAS no. 1694-09-3) (J-CHECK, 2016). Concentration of inoculum i.e, sludge used was 30 mg/l and initial substance conc. used in the study was 100 mg/l. The percentage degradation of read across substance CI acid violet 49 was determined to be 1% by BOD, 4% by TOC removal and 0% by HPLC in 28 days. Thus, the substance CI acid violet 49 is not expected to be readily biodegradable in water.
On the basis of above results for target and read across substance, it can be concluded that the test substance Benzenemethanol, 4-(diethylamino)- alpha,alpha-bis(4-(diethylamino)phenyl)-can be expected to be not readily biodegradable in nature.
Biodegradation in water and sedimet: simulation tests
Estimation Programs Interface (EPI) Suite (2016) prediction model was run to predict the half-life in water and sediment for the test compound 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No. 596 -49 -6). If released in to the environment, 2.5% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- in water is estimated to be 180 days (4320 hrs). The half-life (180 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is moderate to high whereas the half-life period of 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- in sediment is estimated to be 1620.83 days (38900 hrs). Based on this half-life value, it indicates that 4-(diethylamino)-alpha,alpha-bis(4-(diethyl
amino)phenyl)-is persistent in nature.
Biodegradation in soil
The half-life period of Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No. 596 -49 -6) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2016). If released into the environment, 60.8% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of Benzenemethanol, 4-(diethylamino)-alpha, alpha-bis(4-(diethylamino)phenyl)- in soil is estimated to be 360 days (8640 hrs).Based on this half-life value of Benzenemethanol,
4-(diethylamino)-alpha, alpha-bis(4-(diethylamino)phenyl)-, it is concluded that the chemical is highly persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to high.
On the basis of available information, the test substance Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- can be considered to be not readilybiodegradable in nature.
Adsorption / desorption:
Predicted and experimental data of adsorption endpoint for the target chemical p,p',p''-tris(diethylamino)trityl alcohol (Cas no. 596-49-6) and its read across chemical were reviewed to summarize as follows:
From predicted model EPI suite 2016 indicate that the soil adsorption coefficient (Koc) value of chemical p,p',p''-tris(diethylamino)trityl alcohol is estimated to be 631300 L/kg (log KOC = 5.8002) by means of MCI method at 25 deg.C, This Koc value indicates that the substance p,p',p''-tris(diethylamino)trityl alcohol has a Very strong sorption to soil and sediment and therefore have negligible migration potential to groundwater.
Whereas from chemspider predicted database the soil adsorption coefficient i.e Koc value of test substance p,p',p''-tris(diethylamino)trityl alcohol was estimated to be 31552.75 L/Kg i.e Log Koc= 4.4990 at pH 7.4. This Koc value indicates that the substance p,p',p''-tris(diethylamino)trityl alcohol has a Very strong sorption to soil and sediment and therefore have negligible migration potential to groundwater.
From HSDB database; 2016 the read across chemical gentian violet (Cas no. 548-62-9) indicate the adsorption coefficient (Koc) of substance was found to be 610000 using a structure estimation method based on molecular connectivity indices. This gentian violet is expected to be immobile in soil.
Thus based on the above all studies it is concluded that the test substance p,p',p''-tris(diethylamino)trityl alcohol (Cas no. 596-49-6) is expected to be immobile in soil/sediment.
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