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EC number: 405-430-6 | CAS number: 65143-89-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP, guideline study
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Remarks:
- Not specified in report.
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 405-430-6
- EC Name:
- -
- Cas Number:
- 65143-89-7
- Molecular formula:
- UVCB
- IUPAC Name:
- Reaction mass of Benzene sulfonic acid, hexadecyl(sulfophenoxy)-,disodium salt and Benzene sulfonic acid, - oxibis[hexadecyl]-, disodium salt
- Test material form:
- other: liquid
- Details on test material:
- Test material: DOWFAX XD 8390 (~37% a.i.)
Source: Dow Chemical Europe
Appearance: brown liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Three young adult female albino rabbits of the New Zealand White strain, SPF quality, were obtained from The Broekman Institute, Someren, The
Netherlands. At the time of arrival at the animal house (18-08-1986), they were 10 to 12 weeks old. The animals, ear-marked 2159, 2163 and 2183, were individually housed in plastic cages with perforated floors. A quarantine period of 7 days was observed. Both eyes were inspected on the day o f
exposure to the test substance and found to be intact and normal. The body weights of the animals were measured on the day of dose administration. They were fed standard laboratory animal diet (100 g per day), obtained from Hope Farms, Woerden (LK-01, pellet diameter 4 mm), and
had free access to tap-water. The animal room temperature was 19-21°C (with the exception of days 7, 8 and 9 o f the study when it dropped down t o 16°C twice) and the relative humidity was between 45 and 80 per cent. The artificial light sequence was 12 hours light, 12 hours dark.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- single instillation
- Observation period (in vivo):
- Eyes were examined approximately 1, 24, 48 and 72 hours, and 7, 14 and 21 days after instillation of the test substance.
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- The test substance is applied in a single dose to one of the eyes of the experimental animals; the untreated eye is used to provide control
information. The degree of irritation is evaluated and scored at specific intervals and is further described to provide a complete evaluation of the
toxic effects.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Corneal opacity
- Basis:
- mean
- Time point:
- other: 1, 24, 48 and 72 h and day 7, 14 and 21
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Very slight corneal opacity present at 1, 24, 48 and 72 h.
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 and 72 h and day 7, 14 and 21
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Irritation parameter:
- other: conjunctival- redness
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 21 days
- Irritation parameter:
- other: conjunctival- redness
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 21 days
- Irritation parameter:
- other: conjunctival- redness
- Basis:
- mean
- Time point:
- other: Day 7 and 14
- Score:
- 0.7
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 21 days
- Irritation parameter:
- other: conjunctival- redness
- Basis:
- mean
- Time point:
- other: Day 21
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 21 days
- Irritation parameter:
- other: conjunctival- chemosis
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 2.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- other: conjunctival- chemosis
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- other: conjunctival- chemosis
- Basis:
- mean
- Time point:
- other: Day 7, 14 and 21
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- In all animals the test compound caused slight injection of the blood vessels of the palpebral conjunctivae and nictating membrane and obvious to severe conjunctival swelling one hour after exposure. The swelling decreased quickly to slight and completely returned to normal on day 7. The conjunctival redness increased to moderate in all animals after 24 hours and persisted until day 3. On day 7 in animals 2159 and 2183, slight reddening was still observed; the exposed eye of animal 2163 had returned to normal. In animal 2183, conjunctival reddening was still present on day 21. A Draize score of 7.3 was calculated according to Draize et al . ( 1944). According to the Kay and Calandra interpretation scheme the test substance should be considered as mildly irritating (M2). Signs of systemic intoxication were not observed. In conclusion, exposure of the rabbit's eye to the test substance induced moderate, reversible conjunctival injury in 2/3 rabbits with 1/3 showing persistent damage at Day 21. Based on criteria, the test substance should be labelled as an eye-irritant.
- Other effects:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- Category I
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Dowfax XD 8390 was considered an eye irritant.
- Executive summary:
The acute eye irritation/corrosion potential of DOWFAX 8390, ~37% a.i., was evaluated by instilling 0.1 ml of the test substance into one of the eyes of three female rabbits. Instillation of DOWFAX 8390, into the eyes resulted in corneal epithelial erosion which healed within 7 days, as well as moderate conjunctival reddening after initial marked chemosis. Damage persisted in one animal as slight conjunctival redness at Day 21, the effects were reversible within 21 days two other animals.
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