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EC number: 212-889-4 | CAS number: 877-24-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The skin sensitizing potential for Potassium acid phthalate (CASno-877-24-7) is estimated using OECD QSAR toolbox version 3.4. The test substance is estimated to be not sensitizing in guinea pig.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is from QSAR toolbox version 3.4.
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 3.4.
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- not specified
- Specific details on test material used for the study:
- Name of test material (as cited in study report): Potassium hydrogen phthalate
- Molecular formula: C8H5O4K
- Molecular weight (if other than submission substance): 204.23 g/mole
-InChI: 1S/C8H6O4.K/c9-7(10)5-3-1-2-4-6(5)8(11)12;/h1-4H,(H,9,10)(H,11,12);/q;+1/p-1
-Smiles: c1(c(cccc1)C(=O)[O-])C(O)=O.[K+]
-Substance Type: Organic
-Physical State: Solid - Details on the study design:
- No data
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Route:
- epicutaneous, open
- Vehicle:
- not specified
- Concentration / amount:
- not specified
- Day(s)/duration:
- not specified
- Adequacy of induction:
- not specified
- No. of animals per dose:
- not specified
- Details on study design:
- not specified
- Challenge controls:
- not specified
- Positive control substance(s):
- not specified
- Positive control substance(s):
- not specified
- Reading:
- 1st reading
- Group:
- test chemical
- No. with + reactions:
- 0
- Total no. in group:
- 0
- Clinical observations:
- Not sensitizing
- Remarks on result:
- no indication of skin sensitisation
- Variability:
- not specified
- Test group / Remarks:
- not specified
- Remarks on result:
- not measured/tested
- Interpretation of results:
- other: Not sensitizing
- Conclusions:
- The substance Potassium acid phthalate is estimated to be not sensitizing in guinea pig.
- Executive summary:
The skin sensitizing potential for Potassium acid phthalate is estimated using OECD QSAR toolbox version 3.4.
The test substance is estimated to be not sensitizing in guinea pig.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitization
Various studies for target (Potassium acid phthalate, CASno-877-24-7) and its read across were summarized as follows:
The skin sensitizing potential for Potassium acid phthalate (CASno-877-24-7) is estimated using OECD QSAR toolbox version 3.4. The test substance is estimated to be not sensitizing in guinea pig.
In other study by (SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS – SCCP, 2005) with similar substance (65-85-0)was observed in Human. A Human maximization test was observed for Benzoic acid in 25 human volunteers. When 2% concentration of human volunteers in petrolatum was applied as patch tests for five times in 48 hour over a period of 10 days in 25 human volunteers. When challenged 10-14 d after the induction phase with a final 48 h closed patch test with 2 % benzoic acid in petrolatum. No sensitization was observed in any 25 human volunteers. Therefore Benzoic acid was considered to be non sensitizing in human and cannot be classified as skin sensitizer.
In another study by (Bruce g. hammond, George j. levinskas, Ellen c. robinson, 1987)with similar substance (85-68-7)was observed in human. A skin sensitization test was conducted for Butyl benzyl phthalate (BBP) in 200 human volunteers for 24 hrs. Patches containing undiluted BBP were applied to the skin of 200 human volunteers for 24 hrs, 3 times a week for 5 weeks. After a 2-week rest period when no patches were applied, human test subjects were rechallenged by applying patches containing BBP for 24 hours at previously untreated sites on the skinDuring the induction and challenge phases, application sites were examined for signs of sensitization. No sign of sensitization was observed in any 200 human volunteers after 15 daily applications of a subsequent challenge with BBP. Therefore BBP was not considered to be a skin sensitizer in human repeated insult patch tests.
On the basis of available information for the target as well as read across substance and applying weight of evidence approach, the test substance can be considered as not sensitising to the skin.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Basis of available information for the target Potassium acid phthalate(CAS no-93-18-5) as well as read across andapplying weight of evidence approach, the test substance can be considered as not sensitising to the skin.
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