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EC number: 219-330-3 | CAS number: 2416-94-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1969 (march 14-19, and may 13-30)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles; pre-GLP study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- 20 animals/dose
- Principles of method if other than guideline:
- BASF-Test
- GLP compliance:
- no
- Remarks:
- pre-GLP study
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 2,3,6-trimethylphenol
- EC Number:
- 219-330-3
- EC Name:
- 2,3,6-trimethylphenol
- Cas Number:
- 2416-94-6
- Molecular formula:
- C9H12O
- IUPAC Name:
- 2,3,6-trimethylphenol
- Details on test material:
- - Name of test material (as cited in study report): 2,3-6-Trimethyl-phenol (TMP)
Analytical purity: 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Gassner
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- day /night rhythmus 12/12h
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous Traganth
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2, 16, and 30% (w/v)
- Amount of vehicle (if gavage): no data
- Justification for choice of vehicle: no data
- Lot/batch no. (if required): no data
- Purity: no data
MAXIMUM DOSE VOLUME APPLIED: no data
No further data. - Doses:
- 200, 1600, 3200, 3600, 4000, 5000, 6400 mg/kg bw
- No. of animals per sex per dose:
- 20 animals per dose (10/sex)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: daily (observations); body weight males: 215-250g, female 174-200g
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 600 mg/kg bw
- Remarks on result:
- other: after 7 days; 95% CL not given
- Mortality:
- Deaths occurred at all dose levels with exception of the lowest dose (200 mg/kg bw); see table below.
- Clinical signs:
- 6400-1600 mg/kg bw:
Squatting posture or prone/lateral position (immediately after dosing), calm behaviour, accelerated or superficial respiration, piloerection, moderate secretion of the buccal cavity, masticatory movements, extended hind limbs, apathy, and weak tonus were observed in these groups.
At 5000 and 4000 mg/kg bw, narcosis was observed after approximately 15 minutes. At the day after dosing, surviving animals of these two dose groups exhibited intermittent respiration and piloerection.
The remaining animals were normal by days 3-4.
200 mg/kg bw:
No clinical symptoms were observed. - Body weight:
- no data
- Gross pathology:
- Decedents:
hydrothorax (17 rats)
serous adhesions at the snout (14 rats)
plethora and serosa of the pleura (21 rats)
deposits of the test material in the stomach (2 rats)
Survivors: no pathological changes of the organs
Any other information on results incl. tables
Mortality rates after 1, 24, and 48 hours and after 7 days
Dose [mg/kg] | conc. [%] | no. of rats | 1 h | 24 h | 48 h | 7 d |
6400 | 30 | 20 | 0/20 | 19/20 | 19/20 | 19/20 |
5000 | 30 | 20 | 0/20 | 20/20 | 20/20 | 20/20 |
4000 | 30 | 20 | 0/20 | 15/20 | 16/20 | 16/20 |
3600 | 30 | 20 | 0/20 | 7/20 | 9/20 | 9/20 |
3200 | 30 | 20 | 0/20 | 6/20 | 6/20 | 6/20 |
1600 | 16 | 20 | 0/20 | 3/20 | 3/20 | 3/20 |
200 | 2 | 20 | 0/20 | 0/20 | 0/20 | 0/20 |
Applicant's summary and conclusion
- Executive summary:
10 male and 10 female rats were administered the test substance orally and were observed for 7 days. The acute oral LD50 was 3600 mg/kg bw for both males and females.
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