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EC number: 238-877-9 | CAS number: 14807-96-6
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish life cycle toxicity
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Endpoint:
- long-term toxicity to fish, other
- Remarks:
- (Q)SAR calculated endpoint
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- ECOSAR Program (v1.00)
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
- Analytical monitoring:
- not required
- Vehicle:
- not specified
- Test organisms (species):
- other: Fish species
- Details on test organisms:
- no further information
- Test type:
- other: QSAR model
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 30 d
- Hardness:
- not applicable. QSAR model
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Dissolved oxygen:
- not applicable. QSAR model
- Salinity:
- not applicable. QSAR model
- Details on test conditions:
- Chem Name : Talc (Mg3H2(SiO3)4)
Molecular Wt: 379.27
Henry's LC : 5.54e-029 atm-m3/mole (calc VP/Wsol)
Vapor Press : 1.11e-022 mm Hg (Mpbpwin program)
Liquid VP : 1.15e-019 mm Hg (super-cooled)
Melting Pt : 330 deg C (Mpbpwin program)
Log Kow : -9.4 (Kowwin program)
Soil Koc : 31.82 (KOCWIN MCI method) - Reference substance (positive control):
- no
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 5 979.718 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: (Q)SAR prediction
- Remarks on result:
- other: non-toxic , as determined by (Q)SAR
- Details on results:
- A NOEC value of 5979.718 mg/L has been calculated for the effects of the test substance on the mortality of the fish taxonomic group. This result signifies that the test substance is not expected to be toxic .
- Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- A NOEC value of 5979.718 mg/L has been calculated for the effects of the test substance on the mortality of the fish taxonomic group. This result signifies that the test substance is not expected to be toxic .
The ECOSAR QSAR model predicts that the NOEC for freshwater fish would to be 5979.718 mg/l .This result signifies that the test substance is not expected to be toxic . - Executive summary:
The ECOSAR QSAR model predicts that the NOEC for freshwater fish would to be 5979.718 mg/l .This result signifies that the test substance is not expected to be toxic .
- Endpoint:
- long-term toxicity to fish, other
- Remarks:
- (Q)SAR calculated endpoint
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- ECOSAR Program (v1.00)
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
- Analytical monitoring:
- not required
- Vehicle:
- not specified
- Test organisms (species):
- other: Fish species
- Details on test organisms:
- no further information
- Test type:
- other: QSAR model
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 30 d
- Hardness:
- not applicable. QSAR model
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Dissolved oxygen:
- not applicable. QSAR model
- Salinity:
- not applicable. QSAR model
- Details on test conditions:
- Chem Name : Talc (Mg3H2(SiO3)4)
Molecular Wt: 379.27
Henry's LC : 5.54e-029 atm-m3/mole (calc VP/Wsol)
Vapor Press : 1.11e-022 mm Hg (Mpbpwin program)
Liquid VP : 1.15e-019 mm Hg (super-cooled)
Melting Pt : 330 deg C (Mpbpwin program)
Log Kow : -9.4 (Kowwin program)
Soil Koc : 31.82 (KOCWIN MCI method) - Reference substance (positive control):
- no
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 412.648 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: (Q)SAR prediction
- Remarks on result:
- other: non-toxic , as determined by (Q)SAR
- Details on results:
- A NOEC value of 1412.648 mg/L has been calculated for the effects of the test substance on the mortality of the marine fish taxonomic group. This result signifies that the test substance is not expected to be toxic .
- Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- A NOEC value of 1412.648 mg/L has been calculated for the effects of the test substance on the mortality of the fish taxonomic group. This result signifies that the test substance is not expected to be toxic .
The ECOSAR QSAR model predicts that the NOEC for marine water fish would to be 1412.648 mg/l .This result signifies that the test substance is not expected to be toxic . - Executive summary:
The ECOSAR QSAR model predicts that the NOEC for marine water fish would to be 1412.648 mg/l .This result signifies that the test substance is not expected to be toxic .
Referenceopen allclose all
Overview of QSARs estimations onlong-term aquatic toxicity of Talc (Mg3H2(SiO3)4) to fish
Method
|
Results |
Remarks |
Reference |
QSAR estimate |
Fish, 96-hr LC50 =89581.016 mg/L (ppm) Fish 30-day ChV = 5979.718 mg/L (ppm)
|
Reliable with restrictions, QSAR estimated data |
ECOSAR Program (v1.00) |
Fish, 96-hr LC50 =89581.016mg/L (ppm)
Fish 30-day ChV =5979.718mg/L (ppm)
Overview of QSARs estimations onlong-term aquatic toxicity of Talc (Mg3H2(SiO3)4) to marine water fish
Method
|
Results |
Remarks |
Reference |
QSAR estimate |
Fish, 96-hr LC50 =110000 mg/L (ppm) Fish 30-day ChV = 1412.648 mg/L (ppm)
|
Reliable with restrictions, QSAR estimated data |
ECOSAR Program (v1.00) |
Fish, 96-hr LC50 =110000mg/L (ppm)
Fish 30-day ChV =1412.648 mg/L (ppm)
Description of key information
The substance is inorganic almost insoluble powder in aqueous solution and Talc (Mg3H2(SiO3)4) is not expected to be harmful to aquatic life. The material is non-biodegradable, retaining its structure in the environment. At normal water course pH’s this material is stable. It does not hydrolyze in water .The majority of the applications for which this substance is used will not result in the material being released to water courses directly. If low concentrations do get through the water treatment process and enter the water course, the fact that the material does not biodegrade, is stable, not hydrolyses suggest that transfer across biological membranes is unlikely. Short term aquatic toxicity tests reported in the literature on fish (LC50 Brachydanio rerio (Zebra fish) >100000 mg/L/24 hr; for Talc) show this substance is not toxic to aquatic life. On this basis the need for long term aquatic testing is waived. Therefore testing for Long-term toxicity to fish does not need to be performed.
The ECOSAR QSAR model predicts that the NOEC for freshwater fish would to be 5979.718 mg/l .This result signifies that the test substance is not expected to be toxic .
The ECOSAR QSAR model predicts that the NOEC for marine water fish would to be 1412.648 mg/l .This result signifies that the test substance is not expected to be toxic .
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 5 979.718 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 1 412.648 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
