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Diss Factsheets
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EC number: 214-230-6 | CAS number: 1115-70-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Aquatic toxicity of metformin HCl
Study Type |
Organism |
Effect concentation |
Acute toxicity (TAD 4.08) |
Daphnia magna | 48h-NOEC: 78 mg/L;48h-EC50: 130 mg/L |
Acute toxicity (EU C.2) |
Daphnia magna | 48h-EC50: 64 mg/L (literature study, supportive information) |
Acute toxicity (TAD 4.11) | Lepomis macrochirus | 96h-NOEC: 982 mg/L; 96h-LC50: >982 mg/L |
Chronic toxicity (OECD 211) | Daphnia magna | 21d-NOEC: ≥32 mg/L |
Chronic/Acute toxicity Algae (EU C.3) | Desmodesmus subspicatus | 72h-EC50: >320 mg/L |
Chronic toxicity (ISO /WD20079) | Lemna minor | 7d-EC50: 110 mg/L |
Chronic toxicity (OECD 210) | Danio rerio | 34d-NOEC: ≥12 mg/L |
In general, metformin HCl has a very low hazardous potential on
aquatic organisms. In acute aquatic toxicity tests, metformin HCl did
not cause any adverse effects to fish (Lepomis macrochirus) and only
weak effects to invertebrates (Daphnia magna). Chronic toxicity testing
with aquatic organisms also resulted in either no (Desmodesmus
subspicatus, Daphnia magna, Danio rerio) or weak (Lemna minor) adverse
effects at the concentrations tested. The lowest NOEC from aquatic
toxicity studies was the 34d-NOEC of ≥12
mg/L obtained in the Early life stage test with Danio rerio.
Tests on Microbial Inhibition
Study Type |
Organism |
Effect concentation |
Microbial growth inhibition (FDA TAD 4.02) |
Azotobacter chroococcum | MIC: 800 mg/L |
Aspergillus clavatus | MIC: >1000 mg/L | |
Penicillium canescens | MIC: >1000 mg/L | |
Chaetomium globosum | MIC: >1000 mg/L | |
Pseudomonas fluorescens | MIC: >1000 mg/L | |
Anabaena flos-aquae | MIC: 100 mg/L | |
Bacillus megaterium | MIC: >1000 mg/L | |
Respiration inhibition | Activated sludge | 3-hours EC50: 233 mg/L |
DOC removal | Activated sludge | 24-hours EC50: >250 mg/L |
Nitrification inhibition | Activated sludge | EC50: 48-65 mg/L |
Studies on microbial growth inhibition, respiration inhibition and
nitrification inhibition did not result in any inhibition at
concentrations below 100 mg/L.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.