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EC number: 925-462-9 | CAS number: 1182723-73-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Read-across, GLP study, no guideline mentioned
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 116649-85-5
- Cas Number:
- 116649-85-5
- IUPAC Name:
- 116649-85-5
- Reference substance name:
- Bay u 3405
- IUPAC Name:
- Bay u 3405
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Winkelmann, Borchen, Germany
- Strain: Bor:WISW (SPF Cpb)
- Age at study initiation: adult (187 - 203 g)
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: at least 5 days
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5% tylose mucilage
- Details on oral exposure:
- - Application volume: 20 mL/kg bw
- Doses:
- Males: 1000, 1250, 1600, 1500, 2500, 4000, and 5000 mg/kg bw
Females: 630, 1000, 1250, 1600, and 2500 mg/kg bw - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: at least once daily (clinical signs, mortality) or once weekly (weight gain)
- Necropsy of survivors performed: yes - Statistics:
- none
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 000 - 1 250 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Doses of 1250 to 4000 mg/kg bw in males and 1000 to 1250 mg/kg bw led to 20 to 80% mortality. All males died in the 5000 mg/kg bw group and all females died in the 1600 and 2500 mg/kg bw groups.
- Clinical signs:
- other: No clinical signs were seen in males of the 1000 mg/kg bw group. Uncoordinated gait, labored breathing, reduced motility and narrow palpebral fussures were seen in females of the 630 mg/kg bw group and in most of the animals of the higher dose groups. At
- Gross pathology:
- severe disturbance of microcirculation, especially of liver, spleen and lung may explain the symptoms (liver and spleen nearly black, lung dark red)
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
- Executive summary:
The acute oral toxicity of Bay u 3405 was moderate with an LD50 value of 1000 - 1250 mg/kg bw in rats. Mortality occurred at doses of 1000 to 1250 mg/kg bw and higher. Clinical signs were observed as uncoordinated gait, labored breathing, reduced motility and narrow palpebral fussures in females of the 630 mg/kg bw group and in most of the animals of the higher dose groups. In animals that died during the observation period a black discoloration of liver and spleen, and a dark-red discoloration of lung was detected as a consequence of severe disturbance of the microcirculation.
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