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Diss Factsheets
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EC number: 204-841-6 | CAS number: 127-41-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Eye irritation study of the test chemical
- Author:
- Lapczynski et al
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- To assess the ocular irritation potential of the test chemical in rabbits
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-(2,6,6-trimethylcyclohex-2-ene-1-yl)-but-3-ene-2-one
- EC Number:
- 204-841-6
- EC Name:
- 4-(2,6,6-trimethylcyclohex-2-ene-1-yl)-but-3-ene-2-one
- Cas Number:
- 127-41-3
- Molecular formula:
- C13H20O
- IUPAC Name:
- 4-(2,6,6-trimethylcyclohex-2-ene-1-yl)-but-3-ene-2-one
- Details on test material:
- - Name of test material: alpha -Ionone
- Molecular formula: C13H20O
- Molecular weight: 192.3 g/mol
- Substance type:organic
- Physical state:liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data
Test system
- Vehicle:
- other: No vehicle for 100% concentration and DEP for 5% concentration
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- A 0.1 ml aliquot of 100% and 5% the testchemical in DEP
- Duration of treatment / exposure:
- not specified
- Observation period (in vivo):
- 1, 2, 4, 24, 48 and 72 h after instillation.
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- SCORING SYSTEM: no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: after instillation
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Very slight conjunctival irritation was observed in all three rabbits at instillation, which cleared by 24 h
Any other information on results incl. tables
Table 1: Summary of the eye irritation studies
Dose |
Vehicle |
Result |
100% |
No |
No irritation observed |
5% |
DEP |
No irritation observed |
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- Very slight conjunctival irritation was observed in all three rabbits at instillation, which cleared by 24 hours. The instillation of test chemical did not cause any ocular irritation in 3 rabbits after 72 hours of observation. The test chemical can be considered as a non irritant to rabbit eyes
- Executive summary:
An eye irritation test was conducted in three rabbits to assess the ocular irritation potential of the test chemical. A 0.1 ml aliquot of 100% and 5% the test chemical in DEP was instilled into one eye of each of three rabbits with no further treatment. The untreated eye served as a control. Observations for irritation were made immediately after instillation and again at 1, 2, 4, 24, 48 and 72 h after instillation. Very slight conjunctival irritation was observed in all three rabbits at instillation, which cleared by 24 hours. The instillation of test chemical did not cause any ocular irritation in 3 rabbits after 72 hours of observation. The test chemical can be considered as a non irritant to rabbit eyes.
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