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EC number: 700-238-1 | CAS number: 132900-75-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-06-05 to 2008-08-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 2-methylbenzene-1,4-diyl bis{4-[4-(acryloyloxy)butoxy]benzoate}
- EC Number:
- 700-238-1
- Cas Number:
- 132900-75-5
- Molecular formula:
- C35H36O10
- IUPAC Name:
- 2-methylbenzene-1,4-diyl bis{4-[4-(acryloyloxy)butoxy]benzoate}
- Reference substance name:
- 4-({4-[4-(Acryloyloxy)butoxy]benzoyl}oxy)-2-methylphenyl 4-[4-(acryloyloxy)butoxy]benzoate
- IUPAC Name:
- 4-({4-[4-(Acryloyloxy)butoxy]benzoyl}oxy)-2-methylphenyl 4-[4-(acryloyloxy)butoxy]benzoate
- Details on test material:
- Name: Me-3K4A2
Chemical name: Benzoic acid, 4-[4-[(1-oxo-2- propenyl)oxy]butoxy]-, 2-methyl-1,4-phenylene ester
Colour: beige
Physical state: powder
Stability in solution
or suspension: probably stable
Special procedures for dose preparation: prepare freshly
Storage: at room temperature, protected from light
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- HsdRccHan : WIST rats (Full-Barrier), Sex: females, non-pregnant, nulliparous.
Step 1: Body weight at the commencement of the study: 176 – 191 g;
Step 2: Body weight at the commencement of the study: 160 – 164 g.
Three female animals were used for each step.
The animals were derived from a controlled full barrier maintained breeding
system (SPF).
Source: Harlan Winkelmann GmbH, D-33178 Borchen.
The animals were barrier maintained (semi-barrier) in an air conditioned
room
- Temperature: 22 ± 3 °C
- Rel. humidity: 55 ± 10%
- Artificial light, sequence being 12 hours light, 12 hours dark
- Air change: 10 x / hour
- Feeding ad libitum, Altromin 1324 maintenance diet for rats and mice
- Free access to tap water (drinking water, municipal residue control, microbiol. controlled periodically)
- The animals were kept in Macrolon cages on Altromin saw fiber bedding
- Certificates of food, water and bedding are filed at BSL Bioservice
- Adequate acclimatization period (at least 5 days)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- cotton seed oil
- Details on oral exposure:
- For animal no.1 of the first step, 1 g of the test item was diluted with the
vehicle ad 5 mL to gain a dosis of 2000 mg/kg body weight at a volume of 10 mL/kg body weight. For animals no. 2 and 3 of the first step, 2 g of the
test item were diluted with the vehicle ad 10 mL to gain a dosis of 2000 mg/kg body weight at a volume of 10 mL/kg body weight.
For animals no. 1, 2 and 3 of the second step, 2 g of the test item were diluted with the vehicle ad 10 mL to gain a dosis of 2000 mg/kg body weight at a volume of 10 mL/kg body weight. - Doses:
- The test item was administered at a volume of 10 mL/kg body weight.
In the first step the test item was given at a dose of 2000 mg/kg body weight
to a group of 3 female rats. No compound-related mortality was found in
any animals of step 1. Based on the results of the first step and in accordance
with the acute toxic class regime the second step was performed with the
same dose in the same manner to a further groups of 3 female rats.
According to the acute toxic class method regime no further testing was
required since no compound-related mortality was found in any animals of
step 2. - No. of animals per sex per dose:
- 3 females per step
- Control animals:
- no
- Details on study design:
- A careful clinical examination was made several times on the day of dosing. Part of this were at least three observations within the first four hours post dose. Animals were observed once a day thereafter. Cageside observations included changes in the skin and fur, eyes and mucous membranes. Also respiratory, circulatory, autonomic and central nervous systems and somatomotor activity and behaviour pattern were examined. Particular attention was directed to observations of tremor, convulsions, salivation, diarrhoea, lethargy, sleep and coma.
- Statistics:
- not applicable
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: none
- Mortality:
- No signs of toxicity related to dose level used, time of onset and duration were observed in any animal at any time.
- Clinical signs:
- No signs of toxicity related to dose level used, time of onset and duration were observed in any animal at any time.
- Body weight:
- Throughout the 14-days observation period no weight loss was recorded in any surviving animal. The weight gain was within the expected
range. - Gross pathology:
- Beside acute injection of blood vessels in the abdominal region, which is due to the euthanasia injection, no specific gross pathological changes were
found in any animal of any step. - Other findings:
- none
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to GHS (Globally Harmonized Classification System) the test item Me-3K4A2 was not classified (LD50 cut-off: >5000 mg/kg body weight).
- Executive summary:
The acute toxic class method was performed with the test item Me-3K4A2. In the first step the test item was given at a dose of 2000 mg/kg body weight to a group of 3 female rats (HsdRccHan : WIST) in a single exposure via oral gavage. Based on the results of the first step and in accordance with the acute toxic class regime the second step was performed with the same dose in the same manner to a further groups of 3 female rats (HsdRccHan : WIST). Following the acute toxic class regime of OECD 423 no further testing was required.
A careful clinical examination was made several times on the day of dosing. Part of this were at least three observations within the first four hours postdose. Animals were observed once a day thereafter. No signs of toxicity related to dose level used, time of onset and duration were observed in any animal at any time.
No treatment related effect was observed in any animal of any step. Beside acute injection of blood vessels in the abdominal region, which is due to the euthanasia injection, no specific gross pathological changes were found in any animal of any step. Throughout the 14-days observation period no weight loss was recorded in any surviving animal. The weight gain was within the expected
range.
Based on these results and according to OECD Guideline 423, a sufficient estimation of the acute oral toxicity of the test item is provided. Considering the reported data of this toxicity test it can be stated that the test item Me-3K4A2 showed acute oral toxic characteristics. According to GHS (Globally Harmonized Classification System) the test item Me-3K4A2 was not classified (LD50 cut-off: >5000 mg/kg body weight).
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