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Diss Factsheets
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EC number: 237-502-6 | CAS number: 13820-53-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
An acute oral LD50 value of between 500 and 2000 mg/kg bw was determined for disodium tetrachloropalladate in male and female rats (Middleton and Husband, 1978).
No relevant acute inhalation or dermal
toxicity data were identified.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data (report date is March 1978)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Early study, pre-GLP, but scientifically acceptable
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Standard acute method, to assess the acute oral toxicity of the test
- GLP compliance:
- no
- Remarks:
- (prior to GLP)
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Olac (1976) Ltd
Shaws Farm
Blackthorn
Bicester
Oxon
UK
- Age at study initiation: no data
- Weight at study initiation: males mean 215 g; females mean 180 g
- Fasting period before study: overnight
- Housing: polypropylene cages
- Diet (e.g. ad libitum): conventional; ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): “thermostatically controlled”
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): “controlled” - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50 mg/ml
- Amount of vehicle (if gavage): 10 ml/kg bw
- Justification for choice of vehicle: no data
- Lot/batch no. (if required):
- Purity: water for injection
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg bw
DOSAGE PREPARATION (if unusual):
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: - Doses:
- 500 mg/kg bw (main study)
25, 50, 200, 500 and 2000 mg/kg bw (range-finding study) - No. of animals per sex per dose:
- 5/sex (main study)
1/sex/dose (range-finding study) - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: at 4 hr, then daily. Weighed prior to dosing.
- Necropsy of survivors performed: no
- Other examinations performed: none - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 500 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: CL not determined
- Mortality:
- At 2000 mg/kg bw both animals died; the female within 24 h and the male after 6 days. All animals dosed at 500 mg/kg bw survived the observation period.
- Clinical signs:
- other: No overt signs of toxicity were observed in animals treated at 500 mg/kg bw. Symptoms occurring before death in the two animals dosed at 2000 mg/kg bw are not reported.
- Gross pathology:
- There is no indication that gross pathology was examined
- Other findings:
- - Other observations: none
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- An acute oral LD50 value of between 500 and 2000 mg/kg bw was determined for disodium tetrachloropalladate in male and female rats.
- Executive summary:
In an early pre-GLP study, disodium tetrachloropalladate was assessed for acute oral toxicity after single gavage administration in rats. The test substance, available as a brown powder, was given as an aqueous solution at doses of 25-2000 mg/kg bw to one rat of each sex in a range-finding study. A dose of 500 mg/kg bw was administered to groups of five male and female rats in the main study. Body weights were not recorded, except prior to dosing.
Both animals died after exposure to 2000 mg/kg bw, the female within 24 hr and the male after 6 days. No clinical signs were reported for either the deceased animals or the rats dosed at 25-500 mg/kg bw which survived the observation period.
In the main study in which animals were exposed to 500 mg/kg bw, all survived the 14-day observation period. There were no overt signs of toxicity at this dose level. Necropsies were not performed.
An acute oral LD50 value of between 500 and 2000 mg/kg bw was determined for disodium tetrachloropalladate in male and female rats. Based on the results of this acute oral rat study, disodium tetrachloropalladate should be classified for acute oral toxicity (category 4) according to EU CLP criteria (EC 1272/2008).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 500 mg/kg bw
- Quality of whole database:
- Overall, good-quality database which meets REACH Standard Information Requirements.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No relevant acute toxicity human data were identified.
In an early pre-GLP study, disodium tetrachloropalladate was assessed for acute oral toxicity after single gavage administration in rats. The test substance, available as a brown powder, was given as an aqueous solution at substance doses of 25-2000 mg/kg bw to one rat of each sex in a range-finding study. A dose of 500 mg/kg bw was administered to groups of five male and female rats in the main study. Body weights were not recorded, except prior to dosing. Both animals died after exposure to 2000 mg/kg bw, the female within 24 hr and the male after 6 days. No other clinical signs were reported for either the deceased animals or the rats dosed at 25-500 mg/kg bw that survived the observation period. In the main study in which animals were exposed to 500 mg/kg bw, all survived the 14-day observation period. There were no overt signs of toxicity at this dose level. Necropsies were not performed. An acute oral LD50 value of between 500 and 2000 mg/kg bw was determined for disodium tetrachloropalladate in male and female rats (Middleton and Husband, 1978). Based on the results of this acute oral rat study, disodium tetrachloropalladate should be classified for acute oral toxicity (category 4) according to EU CLP criteria (EC 1272/2008).
No relevant acute inhalation toxicity data were identified. However, the compound is not expected to reach the lungs in appreciable quantities (based on respiratory tract deposition modelling data with various palladium compounds). Thus, inhalation will not be a significant route of exposure. Similarly, no acute dermal toxicity data were identified. However, skin contact during production and/or use is expected to be negligible.
Justification for selection of acute toxicity – oral endpoint
Early pre-GLP study, but appears scientifically acceptable, and the only acute oral toxicity study available
Justification for selection of acute toxicity – dermal endpoint
OECD guideline study, to GLP, and the only acute dermal toxicity study available
Justification for classification or non-classification
Based on the results of the available acute oral rat study, disodium tetrachloropalladate should be classified for acute oral toxicity (category 4) according to EU CLP criteria (EC 1272/2008).
No clear evidence of specific target organ toxicity was noted. As such, classification for STOT-SE is not considered appropriate.
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