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Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 208-048-6 | CAS number: 506-64-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.352 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 75
- Dose descriptor starting point:
- NOAEL
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 26.4 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- Corrected inhalatory NOAEC: oral NOAEL*1/sRVrat*ABSoral-rat/ABSinh-human*sRVhuman/wRV Where; ABS: Absorption; sRV: standard Respiratory Volume; wRV: worker Respiratory Volume; Therefore: 15 mg/kg/day divided by (0.38 m3/kg*6.7 m3/10 m3) = 26.4 mg/m3
- AF for dose response relationship:
- 1
- Justification:
- The starting point is a NOAEL
- AF for differences in duration of exposure:
- 6
- Justification:
- Extrapolation fromsubacute animal study to chronic human exposure
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Not required for inhalation
- AF for other interspecies differences:
- 2.5
- Justification:
- Default factor in the absence of specific toxicodynamic data
- AF for intraspecies differences:
- 5
- Justification:
- Default factor for Worker populations
- AF for the quality of the whole database:
- 1
- Justification:
- Complete data set in accordance with regulations
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
- DNEL extrapolated from long term DNEL
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Dose descriptor starting point:
- NOAEL
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 15 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- The starting point is a NOAEL
- AF for differences in duration of exposure:
- 6
- Justification:
- Extrapolation fromsubacute animal study to chronic human exposure
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default scaling factor from oral to dermal
- AF for other interspecies differences:
- 2.5
- Justification:
- Default factor in the absence of specific toxicodynamic data
- AF for intraspecies differences:
- 5
- Justification:
- Default factor for Worker populations
- AF for the quality of the whole database:
- 1
- Justification:
- Complete data set in accordance with regulations
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
The DNEL calculations were prepared following the ECHA Guidance on information requirements and chemical safety assessment, Chapter R.8: Characterisation of dose (concentration)-response for human health. No correction was made for silver content in the test substance.
The DNEL calculations have been conducted only for worker exposure (not consumer). Whilst consumers would be exposed to articles plated with silver as a consequence of using silver cyanide during the plating process, the consumer would not actually be exposed to the test substance itself. Also as oral intake is not considered relevant for workers, only the values for dermal and inhalation have been presented using route to route extrapolation.
The DNELs have been derived for a threshold endpoint since the OECD TG422 study has provided confirmation of this and
default assessment factors have been used to derive the DNELs.
Silver cyanide is significantly irritant to the eye but no DNEL can be set for this endpoint from the data available.
Oral acute toxicity testing of silver cyanide indicates a classification of acute category 2 and a dermal acute study indicates no classification required for this route. Irritancy studies do not provide dose response data so threshold levels could not be identified resulting in difficulty in deriving appropriate irritancy DNELs. However, dermal DNELs are derived by route to route extrapolation from oral exposure. Generally speaking, a long-term DNEL is protective of acute exposure unless there are peak exposures significantly above the average daily exposure (determined from worker exposure studies) so acute DNELs for workers will not be required. The determination of the inhalation DNEL also takes into consideration the Dustiness data for the test substances. These data indicated that the particle size and dosimetry would suggest only extremely marginal exposure to the respiratory airways. Consequently, it is considered that the corrected inhalatory NOAEC should remain unaltered.
When considering the potential for reproductive effects, the OECD422 study for the test substance revealed oral NOAEL for general toxicity that was equal to or below dose levels causing any reproductive, fertility or developmental effects. Therefore, by using the lowest NOAEL from the OECD422 study as the point of departure for DNEL estimation would indicate that the DNELs are also protective of the reproductive toxicity endpoints.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Additional information - General Population
The DNEL calculations have been conducted only for worker exposure (not consumer). Whilst consumers would be exposed to articles plated with silver as a consequence of using silver cyanide during the plating process, the consumer would not actually be exposed to the test substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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