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EC number: 286-122-7 | CAS number: 85187-33-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 June 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- None
- GLP compliance:
- no
- Test type:
- traditional method
- Limit test:
- no
Test material
- Reference substance name:
- Disodium 6-amino-5-[{4-[(2-bromoacryloyl)amino]-2-[(4-methyl-3-sulfonatophenyl)sulfonyl]phenyl}diazenyl]naphthalene-2-sulfonate
- Cas Number:
- 85187-33-3
- Molecular formula:
- C26H19BrN4Na2O9S3
- IUPAC Name:
- Disodium 6-amino-5-[{4-[(2-bromoacryloyl)amino]-2-[(4-methyl-3-sulfonatophenyl)sulfonyl]phenyl}diazenyl]naphthalene-2-sulfonate
- Test material form:
- solid: particulate/powder
- Details on test material:
- Identity - FAT 40066/E TE
Batch - SBL009/LR6G (India)
Appearance - brown powder, solid at 20 °C
Smell - neutral
pH-Value - pH-value of a soln. of 2% (w/w) = 5.2
Expiration date - December 18th, 2018
Storage - to be stored at room-temperature
Constituent 1
- Specific details on test material used for the study:
- Lanasol Red 6G, Product No. 01-146394-100-0, Batch No. (DCT No. 8-0053) 78316/11
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 247 and 345 g
- Fasting period before study: 1 hour
- Housing: housed, individually, in suspended, wire bottom cages
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 74 ± 1
- Humidity (%): 45 to 55
- Photoperiod (hrs dark / hrs light): 12 hours
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Remark on MMAD/GSD:
- None
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: 3-neck, round-bottom, 250 ml Pyrex flask
- Source and rate of air: 0.5 liter of air per minute per rat.
- Duration of exposure:
- 4 h
- Remarks on duration:
- None
- Concentrations:
- The average analytical concentration obtained was 0.42 ± 0.32 mg/L.
- No. of animals per sex per dose:
- None
- Control animals:
- not specified
- Details on study design:
- None
- Statistics:
- None
Results and discussion
- Preliminary study:
- None
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.42 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: The concentration stated above was the maximum attainable aerosol concentration of the test material under the experimental conditions
- Mortality:
- No mortality observed.
- Clinical signs:
- other: Abnormal exposure at 3 to 4 h of exposure and upto 4 h post exposure in all animals. No abnormalities were noted during the 14-day post-exposure period.
- Body weight:
- No effects observed.
- Gross pathology:
- Gross pathological observations showed organs of all animals to be within normal limits.
- Other findings:
- No effects observed
Any other information on results incl. tables
The average mass median diameter of particles for the 4-hour exposure was 3.90 ± 0.44 µm. Abnormal respiration was noted during the last 2 hours of the 4-hour exposure for all animals. This condition persisted for the first 4 hours post-exposure; however, all animals appeared to be normal for the remainder of the post-exposure period. Abnormal exposure at 3 to 4 h of exposure and up to 4 h post exposure in all animals.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LC50 of test substance was 0.42 ± 0.32 mg/l and was found to be non toxic via inhalation.
- Executive summary:
An acute toxicity study via inhalation was performed in 10 laboratory rats (5 males & 5 females) initially weighing between 247 and 345 grams, for 4 hours via the inhalation route at an atmospheric concentration of 0.42 ± 0.32 mg/l, exhibited abnormal respiration for the last half of the exposure. This condition persisted for approximately 4 hours post-exposure. The test substance was generated as a dust using a 3-neck, round-bottom, 250 ml Pyrex flask. No abnormalities were noted during the 14-day post-exposure period. There was no mortality seen. No abnormalities were noted during the 14-day post-exposure period except abnormal exposure at 3 to 4 h of exposure and up to 4 h post exposure in all animals which was subsided from Day1 of observation period. Gross pathological observations showed organs of all animals to be within normal limits. The concentration stated above was the maximum attainable aerosol concentration of the test material under the experimental conditions. The average mass median particle diameter was 3.90 ± 0.44 µm. Gross pathological observations showed organs of all animals to be within normal limits. Based on the study results the LC50 of test substance (FAT 40066) was 0.42 ± 0.32 mg/l.
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