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EC number: 604-612-4 | CAS number: 147900-93-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The in vitro Ames test, the in vitro chromosome aberration test in human lymphocytes and the in vitro mutation test with mouse lymphoma L5178Y cells were chosen as key studies for genetic toxicity, as they represent different aspects of genetic toxicity.
Short description of key information:
IN VITRO AMES TEST: (according to OECD 471 of 1997):
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100, and E. coli WP2 uvr A, all negative without and with metabolic activation.
IN VITRO MAMMALIAN CHROMOSOME ABERRATION TEST (according to OECD 473 of 1997):
3 hours or 21 hours exposure without metabolic activation:
- all tested concentrations negative.
3 hours exposure with metabolic activation (at 2% S9 fraction in final medium):
- At the intermediate test concentrations of WS400151 an increase in chromosome aberrations or in polyploidy was observed, which was biologically not significant All other test concentrations and assays with metabolic activation (at 2% or 5% S9 fraction) were negative regarding chromosome aberrations and regarding polyploidy.
IN VITRO MAMMALIAN CELL GENE MUTATION TEST: (according to OECD 476 of 1997):
3 hours exposure without and with metabolic activation and 24 hours exposure without metabolic activation: all negative.
CYTOTOXICITY
Relevant cytotoxicity was evident in the Ames test in all tested strains (except S. typhimurium TA 100) without and/or with metabolic activation, and in the in vitro mouse lymphoma cell gene mutation and chromsome aberration tests in all experiments both without and with metabolic activation.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the negative results attained in all in vitro genotoxicity studies WS400151 is considered not to be genotoxic and does not warrant any classification regarding mutagenicity according to European classification rules [DIRECTIVE 67/548/EEC and REGULATION (EC) 1272/2008].
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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