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EC number: 695-076-0 | CAS number: 1334513-02-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01 November 2012-17 January 2013
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- Propan-2-yl N-[(S)-(pentafluorophenoxy)(phenoxy)-phosphoryl]-L-alanine
- EC Number:
- 695-076-0
- Cas Number:
- 1334513-02-8
- Molecular formula:
- C18H17F5NO5P
- IUPAC Name:
- Propan-2-yl N-[(S)-(pentafluorophenoxy)(phenoxy)-phosphoryl]-L-alanine
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): GS-606962
- Substance type: organic
- Physical state: white powder
- Lot/batch No.: PSI-172(2)-1-1-12001
- Storage condition of test material: room temperature in the dark
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 0.332 mg/L
- Temp.:
- 20 °C
- pH:
- ca. 6
- Remarks on result:
- other: Water solubility determined as mean concentration of 3 sample solutions. Test temeperature: 20.0±0.5°C
Any other information on results incl. tables
Preliminary test
The preliminary estimate water solubility was 3.55 x 10-4g/L at room temperature.
Definitive test
The concentration (g/L) of the test item in the sample solutions is shown in the following table:
Table 2
Sample Number | Time Shaken at ~ 30°C (hours) | Time Equilibrated at 20°C (hours) | Concentration (g/L) | Solution pH |
1 | 24 | 24 | 3.22 x 10-4 |
6.37 |
2 | 48 | 24 | 3.74x10-4 |
6.19 |
3 | 72 | 24 | 3.22 x 10-4 |
5.99 |
Mean concentration: 3.32 x 10-4g/L at 20.0±0.5°C
Range: 3.00 x 10 -4 to 3.74 x 10-4g/L
Validation The linearity of the detector response with respect to concentration was assessed over the concentration range of 0.116 to 1.16 mg/L. This was satisfactory with correlation coefficient of 1.000 being obtained. Discussion On completion of the equilibration period, the samples were clear and colorless with excess test item present in the test vessels. The solutions were filtered to remove excess test item. After filtration the supernatant was visually observed to be clear and colorless and free from undissolved test item. The preliminary water solubility test indicated that the column elution method should have been performed as the solubility was less than 1x10-2 g/L. However, there was some concern that the test item may not be stable over the extended duration required for the column elution method compared to the flask method; therefore the flask method was used. The result showed good consistency therefore this has been considered not to effect the validity of the result. All individual water solubility results were within ± 15% of the mean, thus satisfying the criteria specified in the guideline for the flask method.Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water solubility of the test item has been determined to be 3.32x10-4 g/L (0.332 mg/L) of solution at 20.0±0.5°C. - Executive summary:
Water solubility
3.32 x 10-4 g/L of solution at 20.0±0.5°C, using the flask method, designed to be compatible with Method A.6 (Water solubility) of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
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