Registration Dossier
Registration Dossier
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EC number: 201-983-0 | CAS number: 90-30-2
Endpoint summary
Administrative data
Description of key information
The data show that the test substance is acutely and chronically very toxic to aquatic organisms.
Additional information
Data for the acute toxicity of N-phenyl-1-naphthylamine are available for all three trophic levels (fish, Daphnia, algae). From these data, it can be concluded that daphnids are the most sensitive organismic group with an 48h-EC50 value of 0.3 mg/L. The lowest effect values obtained for fish was an 96h-LC50 of 0.44 mg/L (nominal) for Oncorhynchus mykiss in a semi-static system. In an algal toxicity test, an 96h-EC50 of 0.93 mg/L (nominal) was obtained. Additional non-standard data are available for the toxicity to amphibians. Several publications were considered as weight of evidence, giving indications for teratogenic effects of the substance to Xenopus laevis and Rana pipiens. Exposure to the substance resulted in teratogenesis and increased mortality with an LC50 value of 2.3 mg/L and an EC50 value of 4.57 mg/L for morphological malformations (Xenopus laevis, 48 h). Another study yielded a NOEC of 5.6 mg/L, teratogenic effects were observed at 5.6 mg/L.
Long-term toxicity data are available for daphnids. One study yielded a 21-d NOEC for reproduction of 0.032 mg/L for reproduction, another study yielded a 21-d NOEC for mortality of 0.02 mg/L. The data show that the test substance is acutely and chronically very toxic to aquatic organisms.
In addition, data are available for toxicity to microorganisms. A test on respiration inhibition with activated sludge resulted in an EC50 of > 10000 mg/L indicating that detrimental effects in STPs are not to be expected.
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