Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 423-740-1 | CAS number: 10461-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Link to relevant study records
- Endpoint:
- screening for reproductive / developmental toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from QSAR Toolbox version 3.3
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: refer below principle
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 3.3
- GLP compliance:
- no
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Route of administration:
- oral: feed
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 2 weeks
- Frequency of treatment:
- ad libitum
- Details on study schedule:
- 15-16 weeks
- Remarks:
- Doses / Concentrations:10, 100 and 300,400,500 mg/kg food.Basis:no data
- No. of animals per sex per dose:
- 10 females per dose.
- Control animals:
- yes, plain diet
- Clinical signs:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Other effects:
- not specified
- Reproductive function: oestrous cycle:
- no effects observed
- Reproductive function: sperm measures:
- no effects observed
- Reproductive performance:
- not specified
- Dose descriptor:
- NOAEL
- Effect level:
- 415.23 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: Reproductive function: estrous cycle ,sperm measures and Gross pathology
- Clinical signs:
- not specified
- Mortality / viability:
- not specified
- Body weight and weight changes:
- not specified
- Sexual maturation:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings:
- not specified
- Remarks on result:
- not determinable
- Reproductive effects observed:
- not specified
- Conclusions:
- In screening study by the oral administration of test substance 2-cyclohexylidene-2-phenylacetonitrile to female Wister rat, no effects were observed on Reproductive function: estrous cycle ,sperm measures and Gross pathology at a dose level of 415.230010986 mg/kg bw/day (nominal). The NOAEL for reproductive toxicity study was considered to be 415.230010986 mg/kg bw/day (nominal).
- Executive summary:
In screening study by the oral administration of test substance 2-cyclohexylidene-2-phenylacetonitrile to female Wister rat, no effects were observed on Reproductive function: estrous cycle ,sperm measures and Gross pathology at a dose level of 415.230010986 mg/kg bw/day (nominal).
The NOAEL for reproductive toxicity study was considered to be 415.230010986 mg/kg bw/day (nominal).
Reference
The prediction was based on dataset comprised from the following descriptors: NOAEL
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(((((((("a" or "b" or "c" or "d" ) and ("e" and ( not "f") ) ) and ("g" and ( not "h") ) ) and "i" ) and "j" ) and ("k" and ( not "l") ) ) and "m" ) and ("n" and "o" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Alkene AND Allyl AND Cycloalkane AND Nitrile by Organic Functional groups
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Allyl AND Cycloalkane AND Nitrile AND Overlapping groups by Organic Functional groups (nested)
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Acetylenic Carbon [#C] AND Aliphatic Carbon [CH] AND Aliphatic Carbon [-CH2-] AND Olefinic carbon [=CH- or =C<] AND Tertiary Carbon by Organic functional groups (US EPA)
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as No functional group found by Organic functional groups, Norbert Haider (checkmol)
Domain logical expression index: "e"
Referential boundary: The target chemical should be classified as No alert found by DNA binding by OECD
Domain logical expression index: "f"
Referential boundary: The target chemical should be classified as Acylation OR Acylation >> Isocyanates and Isothiocyanates OR Acylation >> Isocyanates and Isothiocyanates >> Isocyanates OR Michael addition OR Michael addition >> P450 Mediated Activation to Quinones and Quinone-type Chemicals OR Michael addition >> P450 Mediated Activation to Quinones and Quinone-type Chemicals >> Arenes by DNA binding by OECD
Domain logical expression index: "g"
Referential boundary: The target chemical should be classified as No alert found by Protein binding by OECD
Domain logical expression index: "h"
Referential boundary: The target chemical should be classified as Michael addition OR Michael addition >> Polarised Alkenes OR Michael addition >> Polarised Alkenes >> Polarised alkene - cyano by Protein binding by OECD
Domain logical expression index: "i"
Referential boundary: The target chemical should be classified as No superfragment by Superfragments ONLY
Domain logical expression index: "j"
Referential boundary: The target chemical should be classified as High (Class III) by Toxic hazard classification by Cramer (original) ONLY
Domain logical expression index: "k"
Referential boundary: The target chemical should be classified as No pKa value AND No pKb value by Ionization at pH = 9
Domain logical expression index: "l"
Referential boundary: The target chemical should be classified as Acidic [60,70) OR Acidic [90,100] OR Basic [0,10) by Ionization at pH = 9
Domain logical expression index: "m"
Referential boundary: The target chemical should be classified as Not calculated by Hydrolysis half-life (pH 6.5-7.4) ONLY
Domain logical expression index: "n"
Parametric boundary:The target chemical should have a value of log Kow which is >= 4.08
Domain logical expression index: "o"
Parametric boundary:The target chemical should have a value of log Kow which is <= 5.94
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 415.23 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Data is K2 level from QSAR Toolbox version 3.3
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Toxicity to reproduction:
In screening study by the oral administration of test substance 2-cyclohexylidene-2-phenylacetonitrile to female Wister rat, no effects were observed on Reproductive function: estrous cycle ,sperm measures and Gross pathology at a dose level of 415.230010986 mg/kg bw/day (nominal).
The NOAEL for reproductive toxicity study was considered to be 415.230010986 mg/kg bw/day (nominal).
Short description of key information:
No reproductive toxicity were observed for test chemical 2-cyclohexylidene-2-phenylacetonitrile by oral route.
Justification for selection of Effect on fertility via oral route:
In screening study by the oral administration of test substance 2-cyclohexylidene-2-phenylacetonitrile to female Wister rat, no effects were observed on Reproductive function: estrous cycle ,sperm measures and Gross pathology at a dose level of 415.230010986 mg/kg bw/day (nominal).
The NOAEL for reproductive toxicity study was considered to be 415.230010986 mg/kg bw/day (nominal).
Justification for classification or non-classification
Based upon CLP criteria for classification of substances and considering data from predicted model QSAR Toolbox version 3.3 , it is concluded that the substance 2-cyclohexylidene-2-phenylacetonitrile is unlikely to exhibit reproductive toxicity.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.