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Diss Factsheets
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EC number: 205-778-7 | CAS number: 150-90-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Experimental result performed using standard methods of analysis
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Principles of method if other than guideline:
- Acute Immobilization Study of test material on Daphnia magna in a Semi-Static System (48 Hours)
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Vehicle:
- no
- Details on test solutions:
- The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 100 mg of the test substance in 100 ml of ADaM’s media. Achieving test concentrations of 1 g/L, respectively
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Common name: Daphnia magna
- Source: Own breeding of daphnia magna
-Food: No feeding after hatching
-Photoperiod: 16 hours light and 8 hours dark - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Observations (immobility, pH, Temperature, dissolved oxygen content) were recorded after 24 and 48hours of the start of the experiment.
- Hardness:
- 150.5 mg of CaCO3
- Test temperature:
- 20±2
- pH:
- 7.1
- Nominal and measured concentrations:
- 100 mg/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beaker
- Aeration: No aeration during experiment
- fill volume: 20ml
- No. of organisms per vessel: 10 daphnids
OTHER TEST CONDITIONS
- Photoperiod:16 hours light and 8 hours dark
- Reference substance (positive control):
- not specified
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on nominal concentrations, experimental median effective Concentrations [EC-50 (48 h)] for test material on test daphnia was found to be > 100 mg/L.
- Executive summary:
Daphnia sp., Acute Immobilization Test according to OECD Guideline 203 was conducted for test material. The nominal concentration selected for the experiment were 100mg/L and test Daphnia magna were exposed to these concentration for 48 hours. The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 100 mg of the test substance in 100 ml of ADaM’s media. Achieving test concentrations of 1 g/L, respectively. The median lethal concentration (EC50) for disodium butanedioate on Daphnia magna in a 48 hours study on the basis of immobilization effect was found to be >100 mg/L. Thus, on the basis of this EC50 value and according to CLP criteria for aquatic classification of the substance, it is concluded that the substance, test material does not exhibit short term toxicity to Daphnia. EC50 (48 hours) Experimental = >100 mg/L
Reference
9.1. Immobility
Nominal Concentration (mg/l) |
Number of Daphnids |
Immobility |
||
0 h |
24h |
48h |
||
Control |
10 |
- |
- |
- |
100 |
10 |
- |
- |
- |
pH and oxygen content:
Nominal Concentration (mg/l) |
Number of Daphnids |
pH(mg/L) |
|
|
0 h |
48h |
|
||
Control |
10 |
7.5 |
7.7 |
|
100 |
10 |
7.6 |
7.8 |
|
Nominal Concentration (mg/l) |
Number of Daphnids |
DO(mg/L) |
|
|
0 h |
48h |
|
||
Control |
10 |
7.0 |
6.8 |
|
100 |
10 |
7.0 |
6.8 |
|
Test temperature:
Nominal Concentration (mg/l) |
Number of Daphnids |
Temparature |
|
|
0 h |
48h |
|
||
Control |
10 |
21.2 |
21.5 |
|
100 |
10 |
21.2 |
21.5 |
|
Description of key information
Short term toxicity to aquatic invertebrate:
Daphnia magna Acute Immobilization Test according to OECD Guideline 203 was conducted for test material. The nominal concentration selected for the experiment were 100mg/L and test Daphnia magna were exposed to these concentration for 48 hours. The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 100 mg of the test substance in 100 ml of ADaM’s media. Achieving test concentrations of 1 g/L, respectively. The median lethal concentration (EC50) for disodium butanedioate on Daphnia magna in a 48 hours study on the basis of immobilization effect was found to be >100 mg/L. Thus, on the basis of this EC50 value and according to CLP criteria for aquatic classification of the substance, it is concluded that the substance, test material does not exhibit short term toxicity to Daphnia. EC50 (48 hours) Experimental = >100 mg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Short term toxicity to aquatic invertebrate:
Toxicity of test material was evaluated for aquatic invertebrate based on study report of the test material and data from authoritative database.
Daphnia sp., Acute Immobilization Test according to OECD Guideline 203 was conducted for test material. The nominal concentration selected for the experiment were 100mg/L and test Daphnia magna were exposed to these concentration for 48 hours. The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 100 mg of the test substance in 100 ml of ADaM’s media. Achieving test concentrations of 1 g/L, respectively. The median lethal concentration (EC50) for disodium butanedioate on Daphnia magna in a 48 hours study on the basis of immobilization effect was found to be >100 mg/L. Thus, on the basis of this EC50 value and according to CLP criteria for aquatic classification of the substance, it is concluded that the substance, test material does not exhibit short term toxicity to Daphnia. EC50 (48 hours) Experimental = >100 mg/L.
The above study report was further supported by data fromauthoritative database.The EC50 value of the test substance was evalauted according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) .Test material to Daphnia magna is found to be >1000 mg/L. This value indicates that the substance is not likely to exhibit short term toxicity to aquatic invertebrate.
Based on the above data it can be considered that the test material is not toxic to aquatic invertebrate and can not be classified as per CLP criteria.
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