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EC number: 278-817-9 | CAS number: 78014-16-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on the results of a fully reliable LLNA (according to OECD 429) the test item TAT (Triacetonetriamine) was not a skin sensitiser under the test conditions of this study.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May - Dec 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
- Species:
- mouse
- Strain:
- CBA/Ca
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 1st and 2nd pre-test: 9 - 10 weeks (beginning of treatment); main study: 10 – 11 weeks (beginning of treatment)
- Weight at study initiation:1st and 2nd pre-test: 19.3-19.7 g and 19.9-21-1 g (beginning of treatment); main study: 18.6-23.3 g (beginning of treatment)
- Housing: In groups of 4 (pre-test) and 5 (main study)
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/-2°C°C
- Humidity (%): 45-65%
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 30 May 2012 To: 27 June 2012 - Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 0.5, 1 and 2.5%
- No. of animals per dose:
- 5
- Details on study design:
- A solubility experiment demonstrated that test item solutions at different concentration could be prepared using acetone:olive oil (4+1 v/v) as vehicle.
Due to the corrosive properties of the test item, test item concentrations of 5 and 10% (w/w) were initially tested in one animal, each, in the pre-experiment. Both animals tested, developed an erythema of the ear skin. The animal treated with a concentration of 5% developed a very slight erythema (score 1) on days 3 and 4. The animal treated with the high dose (10%) developed a slight to well visible erythema (score 1 on days 2, 5 and 6; score 2 on days 3 and 4) and a visible swelling of the ears on day 6. Moreover, the animal developed an increase in ear thickness in 54% compared to pre-treatment value. On day 3 both animals developed signs of systemic toxicity, as indicated by a hunched posture and reduced spontaneous activity.
Therefore, a second pre-test was performed using test item concentrations of 1 and 2.5% (w/w). These animals showed no signs of systemic toxicity or excessive local skin irritation.
Thus, the test item in the main study was assayed at 0.5, 1, and 2.5% (w/w). - Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
- Positive control results:
- The periodic positive control experiment was performed with alpha-Hexyl cinnamaldehyde in acetone:olive oil (4+1 v/v) using CBA/CaOlaHsd mice in April 2012.
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: Vehicle Control Group (acetone:olive oil (4+1 v/v)): 874 0.5% test item: 786 1% test item: 854 2.5% test item: 2149
- Key result
- Parameter:
- SI
- Value:
- 0.9
- Test group / Remarks:
- 0.5% test item in acetone:olive oil (4+1 v/v)
- Key result
- Parameter:
- SI
- Value:
- 0.98
- Test group / Remarks:
- 1% test item in acetone:olive oil (4+1 v/v)
- Key result
- Parameter:
- SI
- Value:
- 2.46
- Test group / Remarks:
- 2.5% test item in acetone:olive oil (4+1 v/v)
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Migrated information
- Conclusions:
- The test item was not a skin sensitiser under the test conditions of this study.
- Executive summary:
In the study the test item TAT (Triacetonetriamine) dissolved in acetone:olive oil (4+1 v/v) was assessed for its possible skin sensitising potential.
For this purpose a local lymph node assay was performed using test item concentrations of 0.5, 1, and 2.5% (w/w). The highest concentration tested was the highest concentration that could be achieved whilst avoiding systemic toxicity and excessive local skin irritation as confirmed by a pre-experiment.
The animals did not show any signs of systemic toxicity or local skin irritation during the course of the study and no cases of mortality were observed. In this study Stimulation Indices (S.I.) of 0.9, 0.98 and 2.46 were determined with the test item at concentrations of 0.5, 1, and 2.5% (w/w) in acetone:olive oil (4+1 v/v), respectively.
The test item TAT (Triacetonetriamine) was not a skin sensitiser under the test conditions of this study.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In order to study a possible skin sensitising potential of triacetonetriamine a local lymph node assay was performed. The substance was tested in concentrations of 0.5, 1, and 2.5% (w/w) dissolved in acetone:olive oil (4+1 v/v). The highest concentration tested was the highest concentration that could be achieved whilst avoiding systemic toxicity and excessive local skin irritation as confirmed by a pre-experiment. All treated animals survived the scheduled study period and no signs of systemic toxicity or local skin irritation were observed. Stimulation Indices (S.I.) of 0.9, 0.98 and 2.46 were determined with the test item at concentrations of 0.5, 1, and 2.5% (w/w) in acetone:olive oil (4+1 v/v), respectively. The EC3 value could not be calculated, since none of the tested concentrations induced a S.I. greater than the threshold value of 3. Thus, triacetonetriamine was considered not to be a skin sensitiser under the conditions of this study.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
In a valid GLP compliant local lymph node assay the skin sensitizing potential of triacetonetriamine was assessed. As the result of this study is that the substance is not a skin sensitizer, no classification according to Regulation (EC) No 1272/2008 (CLP) is required.
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