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Diss Factsheets
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EC number: 914-309-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- June - July 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study conducted in accordance to well-described techniques
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
- Principles of method if other than guideline:
- The method used in the present study to assess the pH and the Alkaline reserve was described in the following references:
- JF. Regnier and C. Imbert (1992). Contributions of physical-chemical properties to the evaluation of ocular irritation. Third SPTC Meeting, ATLA 20, 457-465.
- V. Froment (1993). Stage report, Elf Atochem SA. Evaluation du potentiel corrosif des produits chimiques par deux méthodes alternatives au test de Draize : Corrositex, Méthode physico-chimique. - GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- PBN1 mixture
- IUPAC Name:
- PBN1 mixture
- Details on test material:
- Name : REACTION MASS OF AlF3/CrF3/NiF2
Trade name: PBN1 Mixture
Chemical name: Aluminium fluoride / chromium trifluoride / nickel difluoride
CAS number: 7784-18-1 / 7788-97-8 / 10028-18-9
EC number: 914-309-1
Batch number/Supplier: 8204A
Date of reception in the test facility: 15/04/10
Expiration date of the test item: Not reported
Attributed GRL number: 0029/10
Main characteristics:
- Appearance: Solid green spheres (1-4 mm)
- Purity: 99.8%
- Expected water solubility: 0.5 g/L
- Relative density at 20°C: 3.0 at 20 °C
- Certificate of analysis reference: SFL-09-0001
Constituent 1
Test animals
- Species:
- other: Not applicable
- Strain:
- other: Not applicable
- Details on test animals or test system and environmental conditions:
- Not applicable
Test system
- Type of coverage:
- other: Not applicable
- Preparation of test site:
- other: Not applicable
- Vehicle:
- other: Not applicable
- Controls:
- other: Not applicable
- Amount / concentration applied:
- Not applicable
- Duration of treatment / exposure:
- Not applicable
- Observation period:
- Not applicable
- Number of animals:
- Not applicable
- Details on study design:
- See "other information" below
Results and discussion
In vivo
- Irritant / corrosive response data:
- See "other information" below
Any other information on results incl. tables
Preliminary test
Aqueous PBN1 mixture shows an acidic character which is demonstrated by a pH of 4.92 for a 100 g/L solution in water.
A preliminary titration test showed that 1 N sodium hydroxyde allows good conditions for the alkaline reserve determination: 10 mL of the 100 g/L solution were neutralised by approximatively 2.9 mL of 1 N NaOH.
Definitive test
The definitive titration was performed 3 times in the following conditions :
A 20 mL volume of a 100 g/L solution is titrated by 0.1 N NaOH under permanent pH measurement .
Replicates gave following results :
Table 1:Results of neutralization experiments
Replicate |
REACTION MASS OF AlF3/CrF3/NiF2at100 g/L, mL |
NaOH 0.1 N, mL |
Initial pH |
Final pH |
R* |
Log(R) |
I** |
1
|
20 |
6.000 |
5.09 |
7.01 |
1.267 |
0.103 |
9.056
|
2
|
20 |
6.404 |
5.03 |
7.00 |
|||
3
|
20 |
6.602 |
5.02 |
7.02 |
*R is the Alkaline reserve, expressed as number of grams of pure base to neutralise 100 g of test item.
** I is the physical-chemical index defined as follows : I = (14-pH )+ log R when pH is < 7
Conclusions
Under the test conditions, the results are as follows:
Test item |
pH |
log R |
Physical-chemical index (I) |
REACTION MASS OF AlF3/CrF3/NiF2 |
5.05 |
0.103 |
9.056
|
According to the method, the test item is considered:
- as potentially corrosive to the skin if at least 2 of the 3 following criteria are fulfilled:
· pH≤ 2.5 or pH ≥9.5
· log R ≥ 0
· I≥ 10
As only 1 criteria is fulfilled, REACTION MASS OF ALF3/CRF3/NIF2 cannot be considered as potentially corrosive to the skin.
Applicant's summary and conclusion
- Interpretation of results:
- other: non potentially corrosive to the skin
- Remarks:
- Criteria used for interpretation of results: other: see detailed criteria in materials and methods "other information"
- Conclusions:
- According to the test results, reaction mass of ALF3/CRF3/NIF2 cannot be considered as potentially corrosive to the skin.
- Executive summary:
The pH/alkaline reserve of the test item PBN1 mixture or REACTION MASS OF AlF3/CrF3/NiF2(batch N° 8204A) was measured according to the method described in the two following references: JF. Regnier and C. Imbert (1992), and V. Froment (1993).
Under the test conditions, the results are as follows:
Test item
pH
log R
Physical-chemical index (I)
REACTION MASS OF AlF3/CrF3/NiF2
5.05
0.103
9.056
According to the method, the test item is considered:
- as potentially corrosive to the skin if at least 2 of the 3 following criteria are fulfilled:
· pH≤ 2.5 or pH ≥9.5
· log R ≥ 0
· I≥ 10
As only 1 criteria is fulfilled, REACTION MASS OF AlF3/CrF3/NiF2 cannot be considered as potentially corrosive to the skin .
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