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EC number: 229-319-5 | CAS number: 6471-78-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Aquatic toxicity
No experimental data are available regarding aquatic toxicity of 5-methoxy-2-methylsulphanilic acid. The substance should be of low concern for aquatic toxicity based of predicted values by ECOSAR v1.11 and based on read-across data with 4-aminotoluene-3-sulfonic acid .
Acute toxicity:
Predicted value by ECOSAR v.1.11 for 5-methoxy-2-methylsulphanilic are:
LC50 96h fish = 2.24*e^5 mg/l
LC50 48h Daphnid = 92436.563 mg/l
EC50 96h green algae = 18447.344 mg/l
The data reported in SIDS Dossier of 4-aminotoluene-3-sulfonic acid approved at SIAM 16 (27 -30 May 2003) regarding a compound with similar structure (4-aminotoluene-3-sulfonic acid) are:
Oryzias latipes LC50 96h > 10 mg/l
Daphnia magna EC50 48h > 10 mg/l
Selenastrum capricornutum EC 72h growth rate> 10 mg/l
Chronic toxicity:
There are no studies available for chronic toxicity to aquatic environment of 5-methoxy-2-methylsulphanilic acid. An estimated value of chronic value Daphnid for 5-methoxy-2-methylsulphanilic acid has been calculated by ECOSAR V.1.11 and it is of none concern (ChV Daphnid= 3714.701 mg/l).
The data reported in SIDS Dossier of 4-aminotoluene-3-sulfonic acid approved at SIAM 16 (27 -30 May 2003) regarding a compound with similar structure (4-aminotoluene-3-sulfonic acid) is:
NOEC Daphnia magna 21 days = 3.2 mg/l.
The predicted data for 5-methoxy-2-methylsulphanilic acid are higher and less worrying than the experimental data obtained for a similar substance (4-aminotoluene-3-sulfonic acid). In SIDS Dossier of 4-aminotoluene-3-sulfonic acid approved at SIAM 16 (27 -30 May 2003) this substance is evaluate of low concern for aquatic environmental and for analogy the same considerations should be done for 5-methoxy-2-methylsulphanilic acid.
Sediment toxicity
No data available.
Terrestrial toxicity
No data available.
Justification for read-across
See attachment document in section 13.
Conclusion on classification
According to CLP Regulation (EC n. 1272/2008), the substance should be not classified as hazardous to the aquatic environment : 5-methoxy-2-methylsulphanilic acid is not ready biodegradable but from predicted values on this substance and from read-across data with 4-aminotoluene-3-sulfonic acid there is no reason of concern.
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