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EC number: 205-371-4 | CAS number: 139-66-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Experimental data from peer reviewed journal
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
- Objective of study:
- other: identification of metabolism products of Diphenyl sulphide
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Details of guidelines not available in the study report
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diphenyl sulphide
- EC Number:
- 205-371-4
- EC Name:
- Diphenyl sulphide
- Cas Number:
- 139-66-2
- Molecular formula:
- C12H10S
- IUPAC Name:
- (phenylsulfanyl)benzene
- Test material form:
- other: Liquid
- Details on test material:
- CAS No: 139-66-2
IUPAC Name: diphenyl sulphide
Nature of the chemical: Organic
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Male Wistar rats (230–280 g) were obtained from Charles River Laboratories (Wilmington, MA, USA). The animals were maintained in a controlled environment of constant temperature (20°C), 50% relative humidity and 12 h light–dark cycles for at least 4 days before use and allowed free access to food and water. The health of all animals was closely monitored throughout the study by determining weight gain or loss.
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- corn oil
- Details on exposure:
- Male Wistar rats in groups of four were pretreated with phenobarbitone (80 mg/kg/day in saline) intraperitoneally (i.p.), beta-naphthoflavone (100 mg/kg/day in corn oil, i.p.) or methimazole (50 mg/kg/day in saline) for three consecutive days. Rats in the control groups received an equivalent amount of the vehicles alone (1 mL/kg). On the fourth day, DPS (50 mg/kg in corn oil, 500 micro litre was administered orally to the appropriate group of rats pretreated with PB, beta-NF, methimazole, saline or corn oil.
The animals were placed individually in glass metabolic cages and urine samples, free of faeces, collected at 24 h intervals (0–24, 24– 48, 48–72 and 72–96 h)
into tubes supported in Dewar flasks containing liquid nitrogen to prevent nonenzymic degradation of metabolic products. The urine samples were stored at −20°C until analysis - Duration and frequency of treatment / exposure:
- 96 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50 mg/kg in corn oil
- No. of animals per sex per dose / concentration:
- 4
- Control animals:
- yes
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- No details available
- Type:
- distribution
- Results:
- No details available
- Type:
- metabolism
- Results:
- : DPS are oxidized to their corresponding sulphones, via a sulphoxide in rats. S-oxidation of these compounds, it is possible that other metabolic pathways may be relevant for the clearance of these simple sulphides.
- Type:
- excretion
- Results:
- The low levels of the sulphoxides of these simple sulphides detected in urine suggest that the sulphoxides are short-lived in rats.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Diphenyl sulphoxide
Diphenyl sulphone
Any other information on results incl. tables
The above results are in agreement with previous studies that have demonstrated that sulphides show a tendency to be oxidized to sulphoxides, which are in turn converted to sulphones in vitro and in vivo.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
In vivo administration of DPS in Male Wistar rats resulted in metabolism via S-oxidation to their corresponding sulphones, via a sulphoxide. These metabolites are eliminated through the urine. It appears that other modes of excretion may contribute to the overall elimination of these sulphides like lung and biliary excretion. Thus, it can be concluded that the chemical diphenyl sulphide (DPS) is not likely to bioaccumulate inside the living organisms and shall exhibit low bio-accumulation potential. - Executive summary:
In vivo administration of DPS in Male Wistar rats resulted in metabolism via S-oxidationto their correspondingsulphones, via a sulphoxide.These metabolites are eliminated through the urine.It appears that other modes of excretion may contribute to the overall elimination of these sulphides like lung and biliary excretion. Thus, it can be concluded that the chemical diphenyl sulphide (DPS) is not likely to bioaccumulate inside the living organisms and shall exhibit low bio-accumulation potential.
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