N-(2-phenoxyphenyl)methanesulphonamide

Endpoint summary

Description of key information

LD50 was estimated to be 1200 mg/kg bw in rat and 1100 mg/kg bw in mice when mice and rats were orally exposed with N-(2-phenoxyphenyl)methanesulfonamide.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Justification for type of information:

Data is from modelling database developed by the National Food Institute, Technical University of Denmark.

Qualifier:

according to guideline

Guideline:

other: Prediction

Principles of method if other than guideline:

Data is predicted using the Danish (Q)SAR Database

GLP compliance:

no

Test type:

other: no data

Limit test:

no

Specific details on test material used for the study:

- Name of test material (as cited in study report): N-(2-phenoxyphenyl)methanesulphonamide
- Molecular formula (if other than submission substance): C13H13NO3S
- Molecular weight (if other than submission substance): 263.316 g/mole
- Smiles notation (if other than submission substance): CS(=O)(=O)Nc1ccccc1Oc2ccccc2
- InChl (if other than submission substance): WSFHNGGYRUTXFN-UHFFFAOYSA-N
- Substance type: Organic
- Physical state: solid

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

not specified

Route of administration:

oral: unspecified

Vehicle:

not specified

Details on oral exposure:

not specified

Doses:

1200 mg/kg bw

No. of animals per sex per dose:

not specified

Control animals:

not specified

Details on study design:

not specified

Statistics:

not specified

Preliminary study:

not specified

Sex:

not specified

Dose descriptor:

LD50

Effect level:

1 200 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 50 % mortality observed

Mortality:

not specified

Clinical signs:

other: not specified

Gross pathology:

not specified

Other findings:

not specified

Reliability Index: 0.53

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

LD50 was estimated to be 1200 mg/kg bw when rats were orally exposed with N-(2-phenoxyphenyl)methanesulfonamide.

Executive summary:

In a prediction done by SSS (2017) using the Danish (Q) SAR Database, the acute oral toxicity was estimated for N-(2-phenoxyphenyl)methanesulfonamide. The LD50 was estimated to be 1200 mg/kg bw when rats were orally exposed with N-(2-phenoxyphenyl)methanesulfonamide.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

1 200 mg/kg bw

Quality of whole database:

Data is Klimisch 2 and from Danish (Q) SAR Database

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Acute oral toxicity:

In different studies, N-(2-phenoxyphenyl)methanesulfonamide has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rats for N-(2-phenoxyphenyl)methanesulfonamide along with the study available on structurally similar read across substance 3-Cyanopyridine (100-54-9) and Isoquinoline ( CAS no 119-65-3). The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.

In a prediction done by SSS (2017) using the Danish (Q) SAR Database, the acute oral toxicity was estimated for N-(2-phenoxyphenyl)methanesulfonamide. The LD50 was estimated to be 1200 mg/kg bw in rat and 1100 mg/kg bw in mice when mice and rats were orally exposed with N-(2-phenoxyphenyl)methanesulfonamide.

In another prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for N-(2-phenoxyphenyl)methanesulfonamide. The LD50 was estimated to be 1291 mg/kg bw when Wistar male and female rats were orally exposed with N-(2-phenoxyphenyl)methanesulfonamide.

Also it is further supported by experimental study given by J-CHECK (Ministry of Health, Labour and Welfare", "Ministry of the Environment" and "National Institute of Technology and Evaluation, J-CHECK , 2010 ) on structurally similar read across substance 3-Cyanopyridine (100-54-9), Crj:CD (SD) male and female rats were treated with 3-Cyanopyridine in the concentration of 0, 1297, 1388, 1485, 1589, 1700 mg/kg/day orally by gavage in Water for injection. Deaths occurred in 1297 mg/kg and more groups for males and in 1388 mg/kg and more groups for females. Hypoactivity, bradypnea, salivation, lacrimation and wheezing were observed in both male and female rats treated with 1297 mg/kg or more on the day of administration. Decrease in body weights was in observed both male and female rats treated with 1297 mg/kg or more on the day after administration. In addition, Pathological lesions were observed in the stomach, lung, liver, urinary bladder and testis of treated rats. Therefore, LD50 was considered to be 1475mg/kg bw for male and 1455 mg/kg bw for female when Crj:CD (SD) male and female rats were treated with 3-Cyanopyridine orally by gavage.  

Further it is supported by experimental data given by ChemIDplus (U.S. National Library of Medicine, ChemIDplusA Toxnet Database, 2017) on structurally similar read across substance Isoquinoline ( CAS no 119-65-3), rats were treated with Isoquinoline in the concentration of 360 mg/kg/day orally. Deaths occurred in 1297 mg/kg and more groups for males and in 1388 mg/kg and more groups for females. 50% mortality was observed in treated rats at 360 mg/kg bw. Therefore, LD50 was considered to be 360 mg/kg bw when rat were treated with Isoquinoline orally.

Thus, based on the above studies and predictions on N-(2-phenoxyphenyl)methanesulfonamide and its read across substances, it can be concluded that LD50 value is less than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, N-(2-phenoxyphenyl)methanesulfonamide can be classified as “Category IV” of acute oral toxicity.

Justification for classification or non-classification

Based on the above studies and predictions on N-(2-phenoxyphenyl)methanesulfonamide and its read across substances, it can be concluded that LD50 value is less than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, N-(2-phenoxyphenyl)methanesulfonamide can be classified as “Category IV” of acute oral toxicity.