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Diss Factsheets
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EC number: 257-399-1 | CAS number: 51765-51-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
LD50 was estimated to be 1200 mg/kg bw in rat and 1100 mg/kg bw in mice when mice and rats were orally exposed with N-(2-phenoxyphenyl)methanesulfonamide.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Data is from modelling database developed by the National Food Institute, Technical University of Denmark.
- Qualifier:
- according to guideline
- Guideline:
- other: Prediction
- Principles of method if other than guideline:
- Data is predicted using the Danish (Q)SAR Database
- GLP compliance:
- no
- Test type:
- other: no data
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): N-(2-phenoxyphenyl)methanesulphonamide
- Molecular formula (if other than submission substance): C13H13NO3S
- Molecular weight (if other than submission substance): 263.316 g/mole
- Smiles notation (if other than submission substance): CS(=O)(=O)Nc1ccccc1Oc2ccccc2
- InChl (if other than submission substance): WSFHNGGYRUTXFN-UHFFFAOYSA-N
- Substance type: Organic
- Physical state: solid - Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 1200 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
- Preliminary study:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 200 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- not specified
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD50 was estimated to be 1200 mg/kg bw when rats were orally exposed with N-(2-phenoxyphenyl)methanesulfonamide.
- Executive summary:
In a prediction done by SSS (2017) using the Danish (Q) SAR Database, the acute oral toxicity was estimated for N-(2-phenoxyphenyl)methanesulfonamide. The LD50 was estimated to be 1200 mg/kg bw when rats were orally exposed with N-(2-phenoxyphenyl)methanesulfonamide.
Reference
Reliability Index: 0.53
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 200 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from Danish (Q) SAR Database
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity:
In different studies, N-(2-phenoxyphenyl)methanesulfonamide has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rats for N-(2-phenoxyphenyl)methanesulfonamide along with the study available on structurally similar read across substance 3-Cyanopyridine (100-54-9) and Isoquinoline ( CAS no 119-65-3). The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.
In a prediction done by SSS (2017) using the Danish (Q) SAR Database, the acute oral toxicity was estimated for N-(2-phenoxyphenyl)methanesulfonamide. The LD50 was estimated to be 1200 mg/kg bw in rat and 1100 mg/kg bw in mice when mice and rats were orally exposed with N-(2-phenoxyphenyl)methanesulfonamide.
In another prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for N-(2-phenoxyphenyl)methanesulfonamide. The LD50 was estimated to be 1291 mg/kg bw when Wistar male and female rats were orally exposed with N-(2-phenoxyphenyl)methanesulfonamide.
Also it is further supported by experimental study given by J-CHECK (Ministry of Health, Labour and Welfare", "Ministry of the Environment" and "National Institute of Technology and Evaluation, J-CHECK , 2010 ) on structurally similar read across substance 3-Cyanopyridine (100-54-9), Crj:CD (SD) male and female rats were treated with 3-Cyanopyridine in the concentration of 0, 1297, 1388, 1485, 1589, 1700 mg/kg/day orally by gavage in Water for injection. Deaths occurred in 1297 mg/kg and more groups for males and in 1388 mg/kg and more groups for females. Hypoactivity, bradypnea, salivation, lacrimation and wheezing were observed in both male and female rats treated with 1297 mg/kg or more on the day of administration. Decrease in body weights was in observed both male and female rats treated with 1297 mg/kg or more on the day after administration. In addition, Pathological lesions were observed in the stomach, lung, liver, urinary bladder and testis of treated rats. Therefore, LD50 was considered to be 1475mg/kg bw for male and 1455 mg/kg bw for female when Crj:CD (SD) male and female rats were treated with 3-Cyanopyridine orally by gavage.
Further it is supported by experimental data given by ChemIDplus (U.S. National Library of Medicine, ChemIDplusA Toxnet Database, 2017) on structurally similar read across substance Isoquinoline ( CAS no 119-65-3), rats were treated with Isoquinoline in the concentration of 360 mg/kg/day orally. Deaths occurred in 1297 mg/kg and more groups for males and in 1388 mg/kg and more groups for females. 50% mortality was observed in treated rats at 360 mg/kg bw. Therefore, LD50 was considered to be 360 mg/kg bw when rat were treated with Isoquinoline orally.
Thus, based on the above studies and predictions on N-(2-phenoxyphenyl)methanesulfonamide and its read across substances, it can be concluded that LD50 value is less than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, N-(2-phenoxyphenyl)methanesulfonamide can be classified as “Category IV” of acute oral toxicity.
Justification for classification or non-classification
Based on the above studies and predictions on N-(2-phenoxyphenyl)methanesulfonamide and its read across substances, it can be concluded that LD50 value is less than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, N-(2-phenoxyphenyl)methanesulfonamide can be classified as “Category IV” of acute oral toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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