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EC number: 237-525-1 | CAS number: 13826-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance 3-phenoxybenzyl alcohol is found to be non toxic by poral administration at doses upto 10 mg/kg/day in Sprague-Dawley rats in an Uterotrophic assay.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Details of guideline not mentioned in publication. Uterotrophic assays was performed on rats using 3-phenoxybenzyl alcohol.
- GLP compliance:
- not specified
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Texas A&M University Department of Comparative Medicine
- Age at study initiation: 40–45 days old
- Weight at study initiation: No data available
- Fasting period before study: No data available
- Housing: in controlled conditions
- Use of restrainers for preventing ingestion (if dermal): Not applicable
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C):23°C
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): lights on, 06:00 h, lights off, 18:00 h
IN-LIFE DATES: From: To: - Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- Gastric intubation
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 3 consecutive days
- Frequency of treatment:
- Daily
- Remarks:
- Doses / Concentrations:
1.0, 5.0, or 10.0 mg/kg/day
Basis:
no data - No. of animals per sex per dose:
- randomly assigned to treatment groups
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- No data available
- Positive control:
- a positive control group was subcutaneously injected with ethinyl estradiol (EE, CAS no. 57-63-6, purity 98%) at a dose of 0.6g/kg/day
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: No data available
- Time schedule: No data available
- Cage side observations checked in table [No.?] were included. No data available
DETAILED CLINICAL OBSERVATIONS: No data available
- Time schedule: No data available
BODY WEIGHT: Yes
- Time schedule for examinations: No data available
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study):
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: No data available
- Compound intake calculated as time-weighted averages from the consumption and body weight gain data: No data available FOOD EFFICIENCY:
- Body weight gain in kg/food consumption in kg per unit time X 100 calculated as time-weighted averages from the consumption and body weight gain data: No data available
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): No data available
- Time schedule for examinations:
No data available
OPHTHALMOSCOPIC EXAMINATION: No data available - Time schedule for examinations: No data available
- Dose groups that were examined: No data available
HAEMATOLOGY: No data available
- Time schedule for collection of blood: No data available
- Anaesthetic used for blood collection: No data available - Animals fasted: No data available - How many animals: No data available
- Parameters checked in table [No.?] were examined. No data available
CLINICAL CHEMISTRY: No data available
- Time schedule for collection of blood: No data available
- Animals fasted: Yes / No / No data No data available
- How many animals: No data available
- Parameters checked in table [No.?] were examined. No data available
URINALYSIS: No data available
- Time schedule for collection of urine: No data available
- Metabolism cages used for collection of urine: No data available
- Animals fasted: No data available
- Parameters checked in table [No.?] were examined. No data available
NEUROBEHAVIOURAL EXAMINATION: No data available - Time schedule for examinations: No data available
- Dose groups that were examined: No data available
- Battery of functions tested: sensory activity / grip strength / motor activity / other: No data available
OTHER: - Sacrifice and pathology:
- Animals were euthanized 24 h after the final dose; and uteri, livers, and kidneys were carefully removed, cleaned of connective tissue, and weighed.
- Other examinations:
- No data available
- Statistics:
- No data available
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Description (incidence and severity):
- No change was observed in control and treated animals liver or kidney weights
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- None of the doses affected uterine wet weight, while EE caused a significant increase in both absolute and relative wet weight (p < 0.001) as compared to animals receiving corn oil only. Additionally, test substance had no effect on liver or kidney weights
- Dose descriptor:
- NOEL
- Effect level:
- 10 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: No effect on uterine wet weight
- Critical effects observed:
- not specified
- Conclusions:
- The NOEL (No Observed Effect Level) for 3-phenoxybenzylic alcohol (13826-35-2) was found to be 10 mg/kg/day in a Uterotrophic assay.
- Executive summary:
Repeated dose toxicity test was performed on pups of Sprague–Dawley rats at different concentrations. Adult female rats were bred and allowed to deliver pups normally.Fourteen days post-surgery vaginal lavage was performed daily for 3 consecutive days and cytology was observed to verify animals were not cycling. 3 consecutive days animals received 1.0, 5.0, or 10.0 mg/kg/day concentration of chemical .Animals were euthanized 24 h after the final dose; and uteri, livers, and kidneys were carefully removed, cleaned of connective tissue, and weighed. No change was observed in control and treated animals liver or kidney weights. And it was observed that 3PBAlc are not estrogenic in adult female Sprague–Dawley rats in vivo .
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 10 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- The data is K2 level as the data has been obtained from the experimental study published in peer reviewed journal.
Repeated dose toxicity: inhalation - systemic effects
Link to relevant study records
- Endpoint:
- repeated dose toxicity: inhalation
- Data waiving:
- exposure considerations
- Justification for data waiving:
- other:
- Critical effects observed:
- not specified
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Link to relevant study records
- Endpoint:
- repeated dose toxicity: dermal
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Critical effects observed:
- not specified
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Repeated Dose Toxicity - Oral:
Laffin et al (2010) conducted studies for 3-phenoxybenzyl alcohol to demonstrate effects on estrogenic activity of Sprague–Dawley rats. Adult female rats were bred and allowed to deliver pups normally. Fourteen days post-surgery vaginal lavage was performed daily for 3 consecutive days and cytology was observed to verify animals were not cycling. 3 consecutive days animals received 1.0, 5.0, or 10.0 mg/kg/day concentration of chemical .Animals were euthanized 24 h after the final dose; and uteri, livers, and kidneys were carefully removed, cleaned of connective tissue, and weighed. No change was observed in control and treated animals liver or kidney weights. The NOEL (No Observed Effect Level) for 3-phenoxybenzylic alcohol (13826-35-2) was found to be 10 mg/kg/day in a Uterotrophic assay.
In another test Laffin et al (2010), the effect of 3-phenoxybenzyl alcohol on the onset puberty was studied. Adult female rats were bred and allowed to deliver pups normally and pups were administered chemical on PND 22 and continuing until vaginal opening (VO) occurred. Control animals received an equal volume of corn oil. Once VO occurred, vaginal lavage was performed daily and cytology was observed until first diestrus (D1) indicating sexual maturity. The NOEL (No Observed Effect Level) for 3-phenoxybenzylic alcohol (13826-35-2) was found to be 10 mg/kg/day since no difference was found between treated and control animals and the smear on the day of VO was either proestrus or estrus in all animals.
Repeated Dose Toxicity - Inhalation:
The vapour pressure of test substance 3-Phenoxybenzyl alcohol was estimated to be 0.000313 Pa at 25°C by Modified Grain Method. Thus, the chemical is not considered to be volatile and thus repeated exposure by the inhaltion route seems unlikely. In addition, the chemical is used as a raw material for the manufacture of pesticides as well as pharmaceutical ingredient and hence repeated exposure by the inhalation route will be unlikely. Thus, this end point was considered for waiver.
Repeated Dose Toxicity - Dermal
In an acute study, the LD 50 value for the New Zealand white rabbits exposed to 3-Phenoxybenzylalcohol (CAS No: 13826-35-2) was found to be 10000 mg/kg. In addition, the chemical is used as a raw material for the manufacture of pesticides as well as pharmaceutical ingredient and hence repeated exposure by the dermal route will be unlikely. Thus, this end point was considered for waiver.
Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
The NOEL (No Observed Effect Level) for 3-phenoxybenzylic alcohol (13826-35-2) was found to be 10 mg/kg/day in a Uterotrophic assay.
Justification for selection of repeated dose toxicity inhalation - systemic effects endpoint:
The vapour pressure of test substance 3-Phenoxybenzyl alcohol was estimated to be 0.000313 Pa at 25°C by Modified Grain Method. Thus, the chemical is not considered to be volatile and thus repeated exposure by the inhaltion route seems unlikely. In addition, the chemical is used as a arw material for the manufacture of pesiticides as well as pharmaceutical ingredient and hence repeated exposure by the inhaltion route will be unlikely. Thus, this end point was considered for waiver.
Justification for selection of repeated dose toxicity dermal - systemic effects endpoint:
In an acute study, the LD 50 value for the New Zealand white rabbits exposed to 3-Phenoxybenzylalcohol (CAS No: 13826-35-2) was found to be 10000 mg/kg. In addition, the chemical is used as a raw material for the manufacture of pesticides as well as pharmaceutical ingredient and hence repeated exposure by the dermal route will be unlikely. Thus, this end point was considered for waiver.
Justification for classification or non-classification
On the basis of available data, the substance 3-phenoxybenzyl alcohol is likely to be non-toxic by repeated oral, inhalative or dermal administration.
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