Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-492-8 | CAS number: 3495-36-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From October 23, 2009 to 26 November 26, 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: vapour pressure balance
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 0.48 kPa
- Conclusions:
- Under the study conditions the vapour pressure of the test substance was determined to be 4.8-E04 Pa at 25⁰C.
- Executive summary:
A study was conducted to determine the vapour pressure of the test substance according to EU Method A.4, in compliance with GLP. The vapour pressure was established using a vapour pressure balance. A sequence of run (five) after a sample of test substance had been under vacuum for approximately 1 h and 45 min was started. Temperature and pressure were taken between 90 and 100⁰C with 1 h dwell at 90⁰C between runs. The vapour pressure was measured over a range of temperatures. To enable extrapolation to 298.15 K, the reading at 97⁰C (run 5) was chosen as this data point gives the highest estimated vapour pressure at any given temperature when a slope of -1500 k is imposed on it. Under the study conditions the vapour pressure of the test substance was determined to be 4.8-E04 Pa at 25⁰C (Atwal S, 2009).
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- A) The study was conducted according to a method similar to OECD Guideline 104. However, no mention of GLP was made. B) Well-defined information were provided on: 1. Compositional information of the test substance (identity and purity) 2. Test method used in the study 3. Detailed test result (vapour pressure data) 4. Definite conclusion
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- not specified
- Principles of method if other than guideline:
- The study was carried out according to a modified static method (OECD Guideline no. 104) wherein the test solution was stirred magnetically and the vapour pressures were measured by a low-pressure heated transducer.
- GLP compliance:
- no
- Type of method:
- static method
- Temp.:
- ca. 17.26 °C
- Vapour pressure:
- ca. 384 Pa
- Remarks on result:
- other: The sample temperature crossed the TCT value here
- Key result
- Temp.:
- ca. 20 °C
- Vapour pressure:
- ca. 466 Pa
- Key result
- Temp.:
- ca. 25 °C
- Vapour pressure:
- ca. 732 Pa
- Key result
- Transition / decomposition:
- yes
- Transition temp.:
- ca. 17 °C
- Vapour pressure at 10°C above transition temperature:
- 848 Pa
- Conclusions:
- Under the study conditions the vapour pressure of the test substance was 466 Pa at 20°C and rose to 732 Pa at 25°C.
- Executive summary:
A study was conducted to determine the vapour pressure of the test substance solution according to a modified static method closely resembling OECD Guideline 104. The test substance solution was stirred magnetically and the vapour pressures were measured by a low-pressure heated transducer. The vapour pressure of the test substance solution was measured over a range of 1 to 39°C. The sample has a phase transition, which should occur at 17°C. The sample remained as a super-cooled liquid at temperatures below 17°C. Under the study conditions the vapour pressure of the test substance was 466 Pa at 20°C and rose to 732 Pa at 25°C (Pelletier M, 1998).
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well conducted and well documented study with reliable results but not run according to GLP.
- Principles of method if other than guideline:
- Method followed unknown, data from technical manual.
- GLP compliance:
- no
- Type of method:
- other: No data
- Key result
- Temp.:
- >= 18 °C
- Vapour pressure:
- > 400 Pa
- Conclusions:
- The vapour pressure of the test substance was determined to be > 400 Pa at ≥18°C.
- Executive summary:
A study was conducted to determine the vapour pressure of the test substance solution using method from Technical Manual, part A: chemical and physical properties, section A3: water activity and colligative properties. Under the study conditions the vapour pressure of the test substance was determined to be > 400 Pa at ≥18°C (Company data, 2008).
Referenceopen allclose all
No statistical analyses were performed because the balance reading was too low and variable. Therefore, it was considered more appropriate to impose a regression slope on a chosen data point to provide an estimate of the maximum value for the vapour pressure at 25⁰C.
Reduced data for Vapour pressure:
Average temperature (°C) |
Temperature Std. dev. |
Average pressure (Pa) |
Pressure Std. dev. |
1/K |
17.26 |
7.60 |
384 |
3.1 |
0.00344 |
19.48 |
8.10 |
461 |
3.6 |
0.00342 |
22.38 |
6.90 |
586 |
0.0 |
0.00338 |
24.74 |
7.40 |
718 |
4.2 |
0.00336 |
27.15 |
3.80 |
848 |
3.7 |
0.00333 |
29.41 |
2.70 |
1005 |
9.7 |
0.00331 |
31.90 |
3.80 |
1168 |
3.6 |
0.00328 |
34.30 |
2.25 |
1377 |
6.50 |
0.00325 |
36.69 |
5.10 |
1602 |
3.4 |
0.00323 |
38.84 |
4.80 |
1789 |
5.1 |
0.00321 |
Description of key information
Solid form: the vapour pressure was determined according to EU Method A.4.
Brine: the vapour pressure was determined according to:
- Modified static method closely resembling OECD Guideline 104.
- Technical manual, Part A: chemical and physical properties, Section A3: water activity and colligative properties.
Key value for chemical safety assessment
- Vapour pressure:
- 466 Pa
- at the temperature of:
- 293 K
Additional information
Solid form: 4.8-E04 Pa at 25⁰C
Brine: 466 Pa at 20°C and rose to 732 Pa at 25°C (method similar to OECD Guideline 104); > 400 Pa at ≥18°C (Technical manual)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.