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Diss Factsheets
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EC number: 201-730-4 | CAS number: 87-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The LD50 of the source substance is 1310 mg/kg bw. In consideration of the molecular weight of both substances (208.25 and 194.2 g/mol), the corrected LD50 for the target substance is 1406.2 mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 406 mg/kg bw
- Quality of whole database:
- The data has been derived from a read-across substance.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The study was performed on the read-across substance isobutyl salicyclate in order to assess the acute oral toxicity.
The methodology of the study was not described, therefore, it is assumed it was not according to OECD guideline. it was not indicated that study was according to GLP as well.
In total 50 rats (10 rats/dose) were treated by oral route with a single dose of the test item at dose 830 mg/kg, 1040 mg/kg, 1310 mg/kg and 5000 mg/kg.
Following the dosing, the animals were observed during 14 days. At the level 1040 mg/kg, 3/10 animals died on Day 2 after dosing. At dose level 1310 mg/kg bw 5/10 animals died (3 on Day 1 and 2 on Day 2 after dosing). At dose level 2050 mg/kg 8/10 animals died (1 on Day 1 and 7 on Day 2 after dosing). At dose level 5000 mg/kg, 9/10 animals died (3 on Day 1, 5 on Day 2 and 1 on Day 3 after dosing). The LD50 was 1310 mg/kg bw. In consideration of the molecular weight of both substances (208.25 and 194.2 g/mol), the corrected LD50 for the tagret substance is 1406.2 mg/kg.
Justification for classification or non-classification
A classification is required as acute oral toxic Cat 4 according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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