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Diss Factsheets
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EC number: 235-970-6 | CAS number: 13074-65-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limited reporting of all aspects of study and ethical concerns regarding use of prison inmates.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- other: study with inmates
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance was applied under occlusion to same site on the interior of the forearm, for five, alternate-day 48-hr periods. The site was pre-treated for 24 hrs with 5% sodium lauryl sulphate before the initial application. After a 10-14 day rest period, patches were applied to previously untreated sites, for 48 hrs, under occlusion.
- GLP compliance:
- no
Test material
- Reference substance name:
- hexyl cyclopentanone
- IUPAC Name:
- hexyl cyclopentanone
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): hexyl cyclopentanone
- Substance type: no data.
- Physical state: no data.
- Analytical purity: no data.
- Impurities (identity and concentrations): no data.
- Composition of test material, percentage of components: no data.
- Isomers composition: no data.
- Purity test date: no data.
- Lot/batch No.: 80-10-75.
- Expiration date of the lot/batch: no data.
- Stability under test conditions: no data.
- Storage condition of test material: no data.
Constituent 1
Method
- Type of population:
- other: prison inmate
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 27
- Sex: male
- Age: 21-45
- Race: white (11/27), black (9/27), Mexican (5/27), oriental (1/27), Asian (1/27) - Controls:
- no data.
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- No sensitisation reactions reported.
Applicant's summary and conclusion
- Conclusions:
- Jasmatone (hexyl cyclopentanone) was found to be not sensitising in a maximisation test in human subjects.
- Executive summary:
In an in vivo maximisation test, conducted in human subjects (prison inmates), Jasmatone (hexyl cyclopentanone) was found to be non sensitising. There were no reactions that were considered to represent skin sensitisation in the 27 subjects tested.
Only limited study details are available and such a test would not gain ethical approval in most countries if conducted today.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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