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EC number: 415-490-5 | CAS number: 141773-73-1 HELVETOLIDE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995-02-15 to 1995-02-20
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The study was conducted according to an internationally recognised method, and under GLP. However, the testing conditions were not the most suitable for the range considered. Purity and isomers composition are available from the notifier. Therefore validation applies with restrictions.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- UK GLP compliance programme (inspected on 31 January 1994 / signed on 16 March 1994)
- Type of method:
- isoteniscope
- Specific details on test material used for the study:
- Storage conditions: metal bottle at room temperature.
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 17.2 Pa
- Remarks on result:
- other: mean of three runs (extrapolated)
- Temp.:
- 25 °C
- Vapour pressure:
- 23.3 Pa
- Remarks on result:
- other: mean of three runs (extrapolated)
- Conclusions:
- Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), << 500 Pa).
- Executive summary:
The vapour pressure of the test substance was measured under GLP according to EU A4 guideline, isoteniscope method.
Three runs were performed, with respectively 21 measurements recorded between 236 and 175°C, 28 measurements recorded between 253 and 197°C, and 22 measurements recorded between 254 and 170°C. The slope and intercept of the linear relashionship between log VP and 1/T were calculated for each run. Vapour pressure of test substance was derived from the mean log VP extrapolated from these equations.
The vapour pressure of the test substance is ca 23.3 Pa at 25°C, and 17.2 Pa at 20°C (extrapolated).
Reference
Run 1:
A fresh sample of test material was boiled for approximately 41 minutes. Temperature and pressure readings (21 pairs) were taken between 236 and 175°C.
The measurements gave the regression for run 1:
Log10VP (Pa) = -2263.675 / T (K) + 9.049
Standard deviation in slope is 14.0177 (0.62%) and SD in intercept is 0.029 (0.32%).
Coefficient of determination was calculated from the data: R2= 0.9993
The above yields a calculated vapour pressure at 298.15 K of 28.597 Pa.
Run 2:
A fresh sample of test material was boiled for approximately 19 minutes. Temperature and pressure readings (28 pairs) were taken between 253 and 197°C.
The measurements gave the regression for run 2:
Log10VP (Pa) = -2354.323 / T (K) + 9.208
Standard deviation in slope is 12.429 (0.53%) and SD in intercept is 0.025 (0.27%).
Coefficient of determination was calculated from the data: R2= 0.9993
The above yields a calculated vapour pressure at 298.15 K of 20.509 Pa.
Run 3:
A fresh sample of test material was boiled for approximately 11 minutes. Temperature and pressure readings (22 pairs) were taken between 254 and 170°C.
The measurements gave the regression for run 3:
Log10VP (Pa) = -2366.434 / T (K) + 9.255
Standard deviation in slope is 13.514 (0.57%) and SD in intercept is 0.028 (0.30%).
Coefficient of determination was calculated from the data: R2= 0.9993
The above yields a calculated vapour pressure at 298.15 K of 20.803 Pa.
The test material did not change in appearance under the conditions used during the determination.
Description of key information
Low volatility.
Key value for chemical safety assessment
- Vapour pressure:
- 17.2 Pa
- at the temperature of:
- 20 °C
Additional information
A reliable experimental study, conducted according to a recognized EC method and under GLP, is available. Despite restrictions due to applicability domain of the method, it is considered as a key study. Measurements were performed between 170 and 254°C, and the extrapolated result at 20°C is retained as key value for purpose of CSA.
It should be noted that, due to the multi-isomers nature of the substance, this result may refer to the most volatile one, as confirmed by a corresponding normal boiling point of 286°C, while the measured range is 282 - 303°C. However, as structures are close and b.p. range limited, vapour pressure is not anticipated to vary significantly between components.
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