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EC number: 217-703-5 | CAS number: 1934-75-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The skin irritation study was performed 1975, following the DOT (Transport Classification) Guidelines, before GLP- and OECD-testing guidelines were available and in force and amended in year 1991. The intact and abraded skin of 6 albino rabbits was employed for this study. The material to be tested (0.5 mg) was introduced beneath the patch. The irritation index is 0.0 and therefore, the test item will be not classified as skin irritant to the rabbit skin.
The substance was tested in an eye irritation study according to OECD 405, and GLP in year 2001. A single application of the test item to the non-irrigated eye of one rabbit produced opalescent corneal opacity, iridial inflammation and severe conjunctival irritation. The test material produced a maximum total score of 66 and therefore, will be classified as Eye Damage 1, H318 according to GHS/CLP classification criteria.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975-08-15
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable for reliability but not in detail documented. Study report meets basic scientific principles. Study was conducted prior to GLP and OECD guideline implementation.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: DOT (Transport-Classification) Guideliens
- Deviations:
- not specified
- Principles of method if other than guideline:
- The study was performed before GLP- and OECD-testing guidelines were available and in force. The intact and abraded skin of 6 albino rabbits was employed for this study.
- GLP compliance:
- no
- Remarks:
- GLP-guidelines not yet in force at date of the study
- Species:
- rabbit
- Strain:
- not specified
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 4, 24 and 48 hours on intact and abraded skin
- Number of animals:
- 6 albino rabbits were employed for this study.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 4, 24 and 48 hour
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 4, 24 and 48 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- no data
- Other effects:
- No data available.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The irritation index is 0.0 and therefore, the test item will be not classified as skin irritant to the rabbit skin.
- Executive summary:
The study was performed 1975, following the DOT (Transport Classification) Guidelines, before GLP- and OECD-testing guidelines were available and in force and amended in year 1991 (Addendum to Lonza Report No. 0155). A couple of substances were tested in one study. The intact and abraded skin of 6 albino rabbits was employed for this study. A series of 6 rabbits was used for testing each substance. The patches consisted of 1.5 inch x 1.5 inch 12 ply gauze squares. The patches were secured to the area by thin bands of adhesive tape (occlusive application). The material to be tested (0.5 mg) was introduced beneath the patch. The entire trunks of the animals were then wrapped in clear plastic trunk bands.
The irritation index is 0.0 and therefore, the test item will be not classified as skin irritant to the rabbit skin.
Reference
Skin reaction |
Reading (hours) |
Individual scores – rabbit no. & sex |
|||||
1 |
2 |
3 |
4 |
5 |
6 |
||
Erytehma/Eschar |
4 24* 48* 72 |
0 0 0 |
0 0 0 |
0 0 0 |
0 0 0 |
0 0 0 |
0 0 0 |
Total of * 0 0 0 0 0 0 |
|||||||
Mean values of * 0.0 0.0 0.0 0.0 0.0 0.0 |
|||||||
Oedema |
4 24* 48* 72 |
0 0 0
|
0 0 0 |
0 0 0 |
0 0 0 |
0 0 0 |
0 0 0 |
Total of * |
|
0 |
0 |
0 |
0 |
0 |
0 |
Mean values of * |
|
0.0 |
0.0 |
0.0 |
0.0 |
0.0 |
0.0 |
Overall mean of * for Erythema/Eschar: 0.0
Overall mean of * for Oedema: 0.0
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 January 2001 - 21 January 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline Study and according to GLP.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- included in study report
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- water
- Controls:
- yes, concurrent no treatment
- Duration of treatment / exposure:
- The upper and lower eyelids were held together for about one second immediately after treatment. An assessment of the initial pain reaction was made accordingly.
- Observation period (in vivo):
- 1 hour, 24, 48 and 72 hours
- Number of animals or in vitro replicates:
- A single rabbit was used.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 1 hour, 24 hours
- Score:
- 15
- Reversibility:
- not reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 48 hours
- Score:
- 30
- Reversibility:
- not reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 72 hours
- Score:
- 45
- Reversibility:
- not reversible
- Remarks on result:
- other: animal humanely killed immediately after observation
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 1 hour, 24 hours, 48 hours, 72 hours
- Score:
- 5
- Max. score:
- 5
- Reversibility:
- not reversible
- Remarks on result:
- other: at 72 hours animal was humanely killed immediately after observation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 12
- Reversibility:
- not reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24 hours, 48 hours
- Score:
- 14
- Reversibility:
- not reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 72 hours
- Score:
- 16
- Reversibility:
- not reversible
- Remarks on result:
- other: animal humanely killed immediately after observation
- Other effects:
- Areas of diffuse corneal opacity were noted in the treated eye one and 24 hours after treatment with areas of translucent corneal opacity at the 48-hour observation and areas of opalescent corneal opacity at the 72-hour observation. Iridial inflammation was noted in the treated eye one hour after treatment and at the 24, 48 and 72-hour observation. Furthermore, the animal was showing signs of pain and discomfort.
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material produced a maximum total score of 66 and therefore, will be classified as Eye Damage 1, H318 according to GHS/CLP classification criteria.
- Executive summary:
The substance was tested in a eye irritation study according to OECD 405, and GLP in year 2001. A single application of the test item to the non-irrigated eye of one rabbit produced opalescent corneal opacity, iridial inflammation and severe conjunctival irritation. The test material produced a maximum total score of 66 and therefore, will be classified as Eye Damage 1, H318 according to GHS/CLP classification criteria.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
OECD Guideline study and according to GLP.
Justification for selection of eye irritation endpoint:
OECD Guideline study and according to GLP.
Effects on eye irritation: corrosive
Justification for classification or non-classification
The irritation index is 0.0 and therefore, the test item will be not classified as skin irritant to the rabbit skin. The test material produced a maximum total score of 66 and therefore, will be classified as Eye Damage 1, H318 according to GHS/CLP classification criteria.
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