Registration Dossier
Registration Dossier
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EC number: 228-036-4 | CAS number: 6092-54-2
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Hexyl chloroformate is expected to rapidly hydrolyse in contact with water to form hexanol (111-27-3 ), hydrogen chloride (CAS 7647-01-0) and carbon dioxide (CAS 124-38-9). No further hydrolysis of hexanol is to be expected as primary alcohols and ethers are generally known to be resistant to hydrolysis.
Key value for chemical safety assessment
Additional information
No experimental data on the hydrolysis of hexyl chloroformate is available. Hydrolysis is the primary and major fate process of the chloroformates category members which were shown to abiotically degrade rapidly with half-lives in the range of minutes (OECD SIDS, 2010). The hydrolysis behavior of hexyl chloroformate is further assessed from experimental data available for the close chemical analogue 2 -ethylhexyl chloroformate (CAS 24468 -13 -1).
The hydrolysis of 2 -ethylhexyl chloroformate was determined in a study according to OECD 111 and in compliance with GLP criteria. From preliminary investigative work, the test material was known to be hydrolytically unstable at environmentally relevant temperatures. Therefore the preliminary test was considered unnecessary. Testing was therefore conducted with sample solutions at pH 4, 7 and 9, maintained at temperatures of 0 and 10°C. Testing at 10°C was performed in duplicate for each pH. Results from testing at pH 4 showed it was necessary to undertake a further test at pH 1.2, with solutions being maintained at 37°C for a period of 24 hours. From the hydrolysis rate constants at different temperatures the half-lives at 25°C were estimated by means of the Arrhenius equation. It was found that at 25°C the half-lives at pH4, pH 7 and pH 9 were 32.9, 30.2 and 20.5 minutes, respectively. At a pH of 1.2 and a test temperature of 37°C the total recovery after 24 hours was less than 1.55%.
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