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Diss Factsheets
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EC number: 205-003-2 | CAS number: 130-95-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: There are no details on the method available. It is a case report.
Data source
Reference
- Reference Type:
- publication
- Title:
- Quinine Sensitivity.
- Author:
- Calnan, C. D. and Caron, G. A.
- Year:
- 1 961
- Bibliographic source:
- Br Med J. 2(5269): 1750–1752
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- It is an experiential report.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Quinine
- EC Number:
- 205-003-2
- EC Name:
- Quinine
- Cas Number:
- 130-95-0
- Molecular formula:
- C20H24N2O2
- IUPAC Name:
- quinine
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Quinine
Constituent 1
Method
- Type of population:
- general
- Route of exposure:
- dermal
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Quinine, even in high concentration, has no irritant or direct toxic action on the skin.
- Executive summary:
In the experiential report of the Department of Dermatology, Royal Free Hospital, London published by Calnan, 1961 the skin irritation and skin sensitisation of quinine was described. A variety of dermatoses have been described in patients taking quinine systemically, and contact dermatitis follow the topical application of quinine. These eruptions are thought to be based on an allergic process. Quinine, even in high concentration, has no irritant or direct toxic action on the skin.
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