Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-860-7 | CAS number: 111-34-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to the Limit test described in OECD TG403. Restriction: purity of TS not reported; concentration analytically not verified, no data on clinical signs or necropsy.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List V.
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani U
- Year:
- 1 954
- Bibliographic source:
- Arch Ind Hyg Occ Med 10: 61-68
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Toxic effects in rats after inhalation exposure for 4 h
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Butyl vinyl ether
- EC Number:
- 203-860-7
- EC Name:
- Butyl vinyl ether
- Cas Number:
- 111-34-2
- Molecular formula:
- C6H12O
- IUPAC Name:
- 1-(ethenyloxy)butane
- Details on test material:
- butyl vinyl ether, no further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Male and female Carworth-Wistar rats were used, 90 to 120 g in weight. Animals were kept on complete diet.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: air
- Details on inhalation exposure:
- Metered atmospheres were generated by using pumps which delivered known amounts of TS to a stream of air. Concentrations are nominal, but not analytically verified; no further details
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 8000 or 16000 ppm corresponding to 33.3 or 66.6 mg/L
- No. of animals per sex per dose:
- 6 rats
- Details on study design:
- Groups of 6 male or female rats were used. Mortalities noted during the 14-day observation period. Effect levels related to male and female rats combined.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 8 000 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: (33.3 mg/L) 0 out of 6 rats died
- Sex:
- male/female
- Dose descriptor:
- LC100
- Effect level:
- 16 000 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: (66.6 mg/L) 6 out of 6 rats died
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 33.3 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: Recommended limit concentration according to OECD TG403 is 5 mg/L
- Mortality:
- no further details
- Clinical signs:
- other: no data
- Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
- Conclusions:
- No mortality was noted (0/6 animals died) in male and female Wistar rats following exposure to 8000 ppm (=33.3 mg/L) for 4 hours and a post exposure observation period of 14 days. However, a dose level of 16000 ppm (66.6 mg/L) for 4 h killed all 6 rats.
The LC50 (4) in rats is >33.3 mg/L (Limit dose according to OECD TG403 ist 5 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.