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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 941-396-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles, but only limited data reported. As the substance is a breakdown product of the target substance, this study is considered valid for read-across.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Comparative toxicity of synthetic and natural glycerin
- Author:
- Hine, C.H. et al.
- Year:
- 1 953
- Bibliographic source:
- Arch Ind Hyg Occup Med 7:282-291, 1953 (47)
- Reference Type:
- secondary source
- Title:
- OECD SIDS Initial Assessment Report For SIAM 14 - Glycerol
- Author:
- OECD
- Year:
- 2 201
- Bibliographic source:
- http://www.inchem.org/documents/sids/sids/56815.pdf
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A group of 6 rabbits were dermally exposed under occlusive consitions for 8 hours with synthetic or natural glycerol in amounts of 6250 to 18700 mg/kg bw.
- GLP compliance:
- no
- Remarks:
- prior to GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Glycerol
- EC Number:
- 200-289-5
- EC Name:
- Glycerol
- Cas Number:
- 56-81-5
- IUPAC Name:
- glycerol
- Details on test material:
- Test material 1:
- Name of test material (as cited in study report): Natural glyerine, achieved from market stock
- Analytical purity: unknown
- Impurities (identity and concentrations): fatty acids and esters
Test material 2:
- Name of test material (as cited in study report): Synthetic glycerin
- Analytical purity: 99.5%
- Impurities (identity and concentrations): mainly water with very small amounts of glycerin polymers and glyceraldehyde
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: "Albino"
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- - Source: local suppliers
- Weight at study initiation: 2.5 - 3.5 kg
- Housing: Metal cages bedded with sawdust housed them in approximately equal groups
- Diet (e.g. ad libitum): commercial animal food pellets of known composition, supplemented weekly with greens
- Acclimation period: quarantined for about two weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 15 -17
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorsal region of trunk
- Type of wrap if used: rubber dam
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 6250 - 18700 mg/kg bw
- Concentration (if solution): 100% - Duration of exposure:
- 8 h
- Doses:
- 6250 - 18700 mg/kg bw
- No. of animals per sex per dose:
- 6 animals in total
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 18 700 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: for natural and synthetic glycerine
- Clinical signs:
- No signs of clinical toxicity were observed for either synthetic or natural glycerol.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- No deaths were observed in a group of 6 rabbits after occlusive dermal application for 8 hours of synthetic or natural glycerol at 18700 mg/kg bw.
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