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Diss Factsheets
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EC number: 247-104-4 | CAS number: 25564-22-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Stduy similar to guideline. Limited substance information (e.g. purity).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Modified Federal Hazardous Substances Labelling Act method.
Test substances are applied to one eye of each of three rabbits gently pulling the lower lid away from the eye ball and placing 0.1 mL in the sac so formed.
Modifications: Area of the cornea and iris affected was assessed as well as intensity.
Eyes are examined 24 hours after teatment and thereafter at daily intervals and graded for corneal, conjunctival and iridial damage. Eyes are examined before application of materials and at daily intervals afterwards with a slit lamp and corneal swelling is measured. - GLP compliance:
- no
- Remarks:
- The study pre-dates the indroduction of GLP in the UK
Test material
- Reference substance name:
- 2-Pentyl cyclopent-2-enone
- IUPAC Name:
- 2-Pentyl cyclopent-2-enone
- Test material form:
- other: liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- 6 New Zealand White rabbits waighing between 1 and 2 kg and aged between 7-9 weeks, in good general health, are used for testing each material. Only one eye of each rabbit is used. All animals are inspected with a hand torch before any treatment and those with spontaneous eye lesions are rejected. Fluorescein is appled to the eye to assist in the detection of corneal lesions. Corneal thickness is also measured before the application of test materials (Burton, 1972. Fd. Cosmet Toxicol. 10 209).
Test system
- Vehicle:
- other: Tween 80
- Controls:
- other: untreated eye of each animal was used as a control
- Amount / concentration applied:
- 0.1 mL of undiluted test material was applied
- Observation period (in vivo):
- Animals are carefully watched during an immediately after application of the test material for signs of discomfort or pain.
Fifteen minutes after application of test materail the eyes are inspected for conjunctival reactions. One day after application of the test material and then at daily intervals for 5 days per week for 3 weeks or undil the eye is considered to be of normal appearance, the eyes are inspected for corneal , conjunctival and iridial reactions. - Number of animals or in vitro replicates:
- Three rabbits were used in this test. Two animals were pre-treated with corneal anaesthetic.
- Details on study design:
- Tools used to assess score: Eyes were examined with the aid of a hand torch for corneal, conjunctival and iridial reactions.
Results and discussion
In vivo
- Other effects:
- No other effects reported.
Any other information on results incl. tables
2-Pentyl cyclopent-2-enone caused moderate corneal opacities, affecting up to all the cornea, in all three rabbits. These opacities were associated with slight or moderate corneal swelling. All the animals has slight conjunctivitis, one animal had slight discharge, and iritis affecting up to all the iris. All three animals developed peripheral pannus, which was still present at the end of the test. (One animal was found dead on day 15, when it still had slight corneal opactiy). All three animals showed discomfort immediately after treatment.
Applicant's summary and conclusion
- Interpretation of results:
- other: moderate to severe irritant
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- Under the conditions of this test 2-pentyl cyclopentenone produced a generally moderate response, though peripheral pannus was produced in all three rabbits. It is very likey to cause pain if it enters the human eye.
- Executive summary:
In an in vivo study, conducted prior to the introduction of GLP or the applicable OECD test guideline, undiluted 2 -Pentyl cyclopentan-2 -enone was applied to one eye of three New Zealand White rabbits.
Under the conditions of this test 2-pentyl cyclopentenone produced a generally moderate response, though peripheral pannus was produced in all three rabbits. It is very likey to cause pain if it enters the human eye.
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