DL-serinohydrazide monohydrochloride

Flammability

Administrative data

Endpoint:

self-heating substances / mixtures

Type of information:

experimental study

Adequacy of study:

key study

Study period:

01 October 2014-08 January 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2015

Report date:

2015

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)

Version / remarks:

UN ST/SG/AC.10/11/Rev.5: Recommendations on the Transport of Dangerous Good
s, Manual of Tests and Criteria, Part III Section 33.3.1 "Substances liable to spontaneous
combustion” (2009).

Deviations:

no

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

DL-serinohydrazide monohydrochloride

EC Number:

259-839-8

EC Name:

DL-serinohydrazide monohydrochloride

Cas Number:

55819-71-1

Molecular formula:

C3H9N3O2.ClH

IUPAC Name:

2-amino-3-hydroxy-propanehydrazide;hydrochloride

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

- Name of test material (as cited in study report): DL Serine hydrazide
- Molecular formula: C3H9N3O2.HCl
- Molecular weight: 155.6 g/mol
- Description: White powder
- Storage condition of test material: At room temperature in the dark under nitrogen
- Expiration date of the lot/batch: 22 April 2016

Results and discussion

Self-heating substances / mixtures

Self-heating substances / mixtures 1

Test procedure:

100 mm sample cube at 140°C

Max. temp. reached:

291

Result:

positive outcome (effect observed)

Remarks on result:

other: After the experiment, the test substance had turned into a expanded black charred residue

Self-heating substances / mixtures 2

Test procedure:

25 mm sample cube at 140°C

Result:

negative outcome (no effect observed)

Remarks on result:

other:

Remarks:

After the experiment, the test substance had turned into a expanded beige brown residue

Self-heating substances / mixtures 3

Test procedure:

100 mm sample cube at 120°C

Result:

negative outcome (no effect observed)

Remarks on result:

other:

Remarks:

After the experiment, the test substance had turned into a off white residue

Any other information on results incl. tables

In the test performed at 140 ± 2°C using a 10 cm sample cube, an exothermic effect of the test substance by self-heating was observed between 16-21 hours. During this effect the test substance reached a maximal temperature of 291°C. According to the guideline, the test is positive when the sample temperature exceeds the oven temperature by 60°C during 24 hour testing time. Based on this, the result is considered positive. After the experiment, the test substance had turned into a expanded black charred residue.

In the test performed at 140 ± 2°C using a 2.5 cm sample cube, no spontaneous ignition occurred and no exothermic effect of the test substance was observed during the entire test period. Therefore this test was considered negative. After the experiment, the test substance had turned into a expanded beige brown residue.

In the test performed at 120 ± 2°C using a 10 cm sample cube, no spontaneous ignition occurred and no exothermic effect of the test substance was observed during the entire test period. Therefore this test was considered negative. After the experiment, the test substance had turned into a off white residue.

Applicant's summary and conclusion

Interpretation of results:

not classified based on GHS criteria

Conclusions:

In a GLP-compliant study performed in accordance with UN-MTC Section 33.3.1 (Test N.4), a positive result was obtained using a 100 mm sample cube at 140°C, a negative result was obtained with a 25 mm sample cube at 140°C and a negative result is obtained with a 100 mm sample cube at 120°C. It was concluded that the test substance is considered a self-heating substance when tested in a 10 cm sample cube at 140°C.