Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-579-6 | CAS number: 13846-22-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was not conducted in compliance with GLP regulations but was well documented.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Custom protocol
- Principles of method if other than guideline:
- Male rats (3/group) were exposed, whole body, to MTDID 34177 at 92.2 ppm (1.30 mg/L, vapor) or 899.5 ppm (12.66 mg/L, vapor) for a single, 1 hour exposure. Control animals were not utilized. Clinical observations (during and post exposure, daily thereafter) and body weights (Days 1, 8, and 15) were recorded. Limited necropsy was performed on all surviving animals on Day 15 post dose.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- MTDID 34177
- IUPAC Name:
- MTDID 34177
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report): MTDID 34177
- Substance type: Mono-constituent
- Physical state: Liquid
- Analytical purity: 98.8%
- Purity test date: 01 October, 2012
- Lot/batch No.: No data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Portage, MI
- Age at study initiation: 6-8 weeks old
- Weight at study initiation: 170-191 grams
- Fasting period before study: No data
- Housing: Group housed in standard solid-bottom plastic cages with bedding
- Diet (e.g. ad libitum): Harlan Teklad Rat/Mouse 2018 Diet (Harlan Teklad, Madison, WI) ad libitum
- Water (e.g. ad libitum): Tap water ad libitum
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.6-23.9
- Humidity (%): 30-70
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 16 January 2013 To: 30 January 2013
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: 40-liter plexiglass chamber
- Exposure chamber volume: 40 liter
- Method of holding animals in test chamber: None: whole body exposure
TEST ATMOSPHERE
- Brief description of analytical method used: Gas chromatographic-electron caputre detector (GC-ECD) method.
- Samples taken from breathing zone: yes - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 1 h
- Concentrations:
- 92.2 ppm (1.30 mg/L, vapor) and 899.5 ppm (12.66 mg/L, vapor)
- No. of animals per sex per dose:
- 3 males/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations were made through out exposure and daily thereafter. Body weights were recorded on Days 1, 8, and 15.
- Necropsy of survivors performed: yes, limited gross necropsy.
- Other examinations performed: clinical signs, body weights
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 6.33 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 1
- Remarks on result:
- other: 4 hour equivalent LC50 calucalted from 1 hr exposure at 12.66 mg/L with no deaths or adverse clinical signs.
- Mortality:
- No mortality occurred during the study.
- Clinical signs:
- other: No abnormal clinical signs were observed.
- Body weight:
- All animals in both groups gained weight during the study.
- Gross pathology:
- No gross lesions or significant findings were noted in any animal upon necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- other: Low dose tested not suitable for classification
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of the study, the 1-hour LC50 of the test article was >899.5 ppm (12.66 mg/L, vapor) and the 4-hour equivalent LC50 is > 6.33 mg/L, vapor.
- Executive summary:
The acute inhalation toxicity of the test article (Colorless liquid, Purity 98.8%, Lot: DVE-3-AH194-ANL0033902) was evaluated in Sprague Dawley rats. The study was not conducted under GLP conditions. The test method was based on a custom protocol. Male rats (3/group) were exposed, whole body, to the test article at 92.2 ppm (1.30 mg/L, vapor) or 899.5 ppm (12.66 mg/L, vapor) for a single, 1 hour exposure. Control animals were not utilized. Clinical observations (during and post exposure, daily thereafter) and body weights (Days 1, 8, and 15) were recorded. Limited necropsy was performed on all surviving animals on Day 15 post dose. All animals in both groups survived to scheduled necropsy. No abnormal clinical signs were observed in any animal during the study period. All animals in both groups gained weight during the study. No gross lesions or significant findings were noted in any animal upon necropsy. Based on the results of the study, the 1-hour LC50 of the test article was >899.5 ppm (12.66 mg/L, vapor) and the 4-hour equivalent LC50 is > 6.33 mg/L, vapor.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.