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Diss Factsheets
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EC number: 209-693-6 | CAS number: 590-90-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented, scientifically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 4-hydroxybutan-2-one
- EC Number:
- 209-693-6
- EC Name:
- 4-hydroxybutan-2-one
- Cas Number:
- 590-90-9
- Molecular formula:
- C4H8O2
- IUPAC Name:
- 4-hydroxybutan-2-one
- Details on test material:
- Name of the test substance used in the study report: Ketobutanol (= 4-Hydroxybutan-2-on)
Physical state: liquid
Substance No. 81/0093
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Acclimatization in the animal care unit for at least one week.
Age of animals at beginning of study: about 12 weeks
Type of cage: type DK-III stainless steel wire mesh cages
Animal identification: identification of groups (5 animals) using cage cards
Room temperature: 20 - 26°C; relative humidity: 45 - 75%; day/night rhythm: 12 h/12 h (6 .00 - 18 .00 hours/18 .00 - 6 .00 hours)
Drinking water: Fully demineralized water each workday, ad libitum; tap water on public holidays, ad libitum
The animals are given no feed for 16 hours before administration, but water is available ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Test concentrations: 21.5, 31.6 and 46.4% (g/v).
Application volume: 10 ml/kg - Doses:
- 2150, 3160 and 4640 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Weight check: Animals of comparable weights (± 10 g) in one cage. Weighing of groups before administration, 2nd weighing 2 d, 2nd weighing 3 d, 3rd weighing 7 d and 4th weighing 13 d after administration.
Cageside observation: Recording of signs and symptoms < 15, 15, 30 min, 1 h, 2 h, 4 h, and 5 h after administration of test substance and then once each workday. Check for moribund and dead animals twice each workday and once daily at weekends and on public holidays.
Pathology: Withdrawal of feed 16 hours before sacrifice with C02, followed by necropsy and grosspathological examination. All animals that die are necropsied as early as possible.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 160 - < 4 640 mg/kg bw
- Mortality:
- male rats: 2150 and 3160 mg/kg: 0/5 after 14 days; 4640 mg/kg: 5/5 after 14 dys
female rats: 2150 mg/kg: 0/5 after 14 days; 3160 mg/kg: 2/5 after 14 days; 4640 mg/kg: 3/5 after 14 days - Clinical signs:
- other: dyspnea, apathy, staggering, trembling, spastic gait, ruffled fur, poor general state
- Gross pathology:
- animals that died: acute congestive hyperemia; lung: intensified hyperemia; intestine: partly reddenisch-mucoid content.
sacrified animals - 2150 mg/kg: nothing abnormal detected; 3160 mg/kg: multiple thickening of the top of the forestomach and concrescence with liver, spleen and peritoneum
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.