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EC number: 620-216-4 | CAS number: 298692-41-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-12-02 - 2003-03-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- isopropyl (diaminophosphoryl) carbamate
- Cas Number:
- 298692-41-8
- Molecular formula:
- C4H12N3O3P
- IUPAC Name:
- isopropyl (diaminophosphoryl) carbamate
- Reference substance name:
- Carbamic acid, (diaminophosphinyl)-1-methylethylester
- IUPAC Name:
- Carbamic acid, (diaminophosphinyl)-1-methylethylester
- Details on test material:
- Purity: > 95 %
Batch no.: P204/98/S-2
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- male
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- other: aqua pro injectione
- Concentration / amount:
- induction by intracutaneous injection:
injection 1: mixture of aqua pro injectione and Freund's Complete Adjuvant 1:1
injection 2: 5 % solution of test item in aqua pro injectione
injection 3: 5 % solution of test item in aquapro injectione/Freund's Complete Adjuvans 1:1
induction by epicutaneous administration:
0.5 g of the 25 % mixture of test item with vaseline
challenge by epicutaneous administration:
0.5 g of the 25 % mixture of test item with vaseline
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: aqua pro injectione
- Concentration / amount:
- induction by intracutaneous injection:
injection 1: mixture of aqua pro injectione and Freund's Complete Adjuvant 1:1
injection 2: 5 % solution of test item in aqua pro injectione
injection 3: 5 % solution of test item in aquapro injectione/Freund's Complete Adjuvans 1:1
induction by epicutaneous administration:
0.5 g of the 25 % mixture of test item with vaseline
challenge by epicutaneous administration:
0.5 g of the 25 % mixture of test item with vaseline
- No. of animals per dose:
- 10
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 25 % (w/w)
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- none
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 48.0. Group: test group. Dose level: 25 % (w/w). No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: none.
- Reading:
- 2nd reading
- Hours after challenge:
- 72
- Group:
- test chemical
- Dose level:
- 25 % (w/w)
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- none
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 72.0. Group: test group. Dose level: 25 % (w/w). No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: none.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- No clinical signs were observed in the course of testing. The body weights and the body weight gain were not affected by the treatment. The intracutaneous injection of the 5 % solution of the test item in aqua pro injectione did not cause any skin reaction. In combination with sensitisation potentiating FCA slight to moderate erythema and oedema were observed. The epicutaneous administration of 25 % mixture of the test item with vaseline did not cause any irritation. The challenge with the 25 % mixture of the test item with vaseline did not cause any irritation signs in all animals. The test item is not to classify as skin sensitiser.
- Executive summary:
No clinical signs were observed in the course of testing. The body weights and the body weight gain were not affected by the treatment. The intracutaneous injection of the 5 % solution of the test item in aqua pro injectione did not cause any skin reaction. In combination with sensitisation potentiating FCA slight to moderate erythema and oedema were observed. The epicutaneous administration of 25 % mixture of the test item with vaseline did not cause any irritation. The challenge with the 25 % mixture of the test item with vaseline did not cause any irritation signs in all animals. The test item is not to classify as skin sensitiser.
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