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Diss Factsheets
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EC number: 203-253-7 | CAS number: 104-93-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 13th, 1979 to September 2th 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-methylanisole
- EC Number:
- 203-253-7
- EC Name:
- 4-methylanisole
- Cas Number:
- 104-93-8
- Molecular formula:
- C8H10O
- IUPAC Name:
- 1-methoxy-4-methylbenzene
- Details on test material:
- - Name of test material (as cited in study report): p-Methylanisole
- Analytical purity: no data given
Constituent 1
- Specific details on test material used for the study:
- Name (as stated in the report): P-Cresyl Methyl Ether
Test concentrations: as supplied (undiluted)
Sample No. 11.336.T11
Apparence: Clear liquid
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
8 New Zealand White rabbits, aged 9-12 weeks are used for each test. The whole dorsal surface is clipped 3-4 days before the test is due to start, and animals in the telogen phase of hair growth are selected.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 24, 48 , 72 hours
- Number of animals:
- 8
- Details on study design:
- Study design:
0.5 ml of the test material and appropriate standards were applied to the clipped dorsum of New Zealand White rabbits for 4 hours under individual semi-occlusive patches. After removal of the patches, the treated areas were wiped and examined for evidence of irritation. The position of the treatment sites were randomized. Skin sites were assessed for skin irritation immediately after treatment, 24, 48 and 72 hours.
Each animal was scored blind and the scores linked to the product after the 72 hours evaluation had been completed. Sites were scored for erythema, edema, cracking and scaling and any other feature using an 8-point achored ordinate scale ranging from "a" (very slight) to "h" (severe). Reaction grades are converted into a numerical score used to calculate the total irritation score per site, and a mean irritation score per site per day.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: 1242, 1243, 1240, 1241, 1238, 1209, 1211
- Time point:
- 24 h
- Score:
- 3
- Irritation parameter:
- erythema score
- Basis:
- animal: 1236
- Time point:
- 24 h
- Score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal: 1242, 1240, 1241, 1238,1211
- Time point:
- 24 h
- Score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal: 1243
- Time point:
- 24 h
- Score:
- 3
- Irritation parameter:
- edema score
- Basis:
- animal: 1236
- Time point:
- 24 h
- Score:
- 8
- Irritation parameter:
- edema score
- Basis:
- animal: 1209
- Time point:
- 24 h
- Score:
- 6
- Irritation parameter:
- erythema score
- Basis:
- animal: 1242, 1240, 1241, 1236, 1238, 1211
- Time point:
- 48 h
- Score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal: 1243, 1209
- Time point:
- 48 h
- Score:
- 3
- Irritation parameter:
- edema score
- Basis:
- animal: 1242, 1243, 1211
- Time point:
- 48 h
- Score:
- 3
- Irritation parameter:
- edema score
- Basis:
- animal: 1240, 1209
- Time point:
- 48 h
- Score:
- 6
- Irritation parameter:
- edema score
- Basis:
- animal: 1236
- Time point:
- 48 h
- Score:
- 8
- Irritation parameter:
- erythema score
- Basis:
- animal: 1242, 1236, 1209
- Time point:
- 72 h
- Score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal: 1243, 1241, 1211
- Time point:
- 72 h
- Score:
- 3
- Irritation parameter:
- erythema score
- Basis:
- animal: 1240, 1238
- Time point:
- 72 h
- Score:
- 6
- Irritation parameter:
- edema score
- Basis:
- animal: 1242
- Time point:
- 72 h
- Score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal: 1243, 1241
- Time point:
- 72 h
- Score:
- 3
- Irritation parameter:
- edema score
- Basis:
- animal: 1240, 1236, 1238, 1209
- Time point:
- 72 h
- Score:
- 6
- Irritation parameter:
- edema score
- Basis:
- animal: 1211
- Time point:
- 72 h
- Score:
- 8
- Irritant / corrosive response data:
- A single application of P - Cresyl methyl ether produced generally fairly distinct erythema and d'istinct oedema, two animals showed fairly well developed to well developed oedema at 24 hr. By 48 hr and 72 hr there was generally fairly distinct to fairly well developed erythema and oedema; one animal had a pale brown area over 1/3 of the treatment site. The level of response was greater than that produced by the control, Diethyl Phthalate, and broadly similar to that produecd by the controls, Cyclamen aldehyde and Geraniol.
Any other information on results incl. tables
Under the conditions of this test P-cresyl methyl ether is moderately irrritant to rabbit skin. This level of response is greater than that produced by Cyclamen aldehyde and Geraniol.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- According to the authors the test material at 100% was moderately irritating to rabbit skin under the experimental conditions chosen.
- Executive summary:
New Zealand White rabbits were assessed for dermal irritation following a 4 hour exposure under semi-occlusive conditions. Application sites were scored for immediately after exposure, 24, 48 and 72 hours later. The results showed fairly distinct erythema and edema at 24 hrs and by 48 and 72 hrs these reactions were between fairly distinct and fairly well developed. Under the conditions of this test, the test material was considered a moderate irritant to rabbit skin.
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