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Diss Factsheets
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EC number: 290-058-5 | CAS number: 90063-97-1 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Mentha arvensis, Labiatae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Study period:
- 1974
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Read across from peppermint oil. The documentation is a summary of methods and results, individual scores are not included.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In an eye irritation test following the method of Draize, 0.1 ml of 10, 20, 30, 40, 50, or 60% test substance in olive oil was applied to the right eye (conjunctival sac) of rabbits (8 animals/dose group). The upper and lower lids were held closed for one minute. Afterwards, the eyes of 4 animals were rinsed for 1 minute with physiological saline and those of the remaining 4 were not rinsed. The test substance mixture was warmed at the 3 highest concentrations to keep the mixture fluid.
- GLP compliance:
- no
Test material
- Reference substance name:
- Brazilian menthol (peppermint oil)
- IUPAC Name:
- Brazilian menthol (peppermint oil)
- Reference substance name:
- Peppermint oil
- IUPAC Name:
- Peppermint oil
- Details on test material:
- - Name of test material (as cited in study report): Brazilian menthol (peppermint oil)
- Physical state: Liquid
- Analytical purity: No data
- Lot/batch No.: No data
- Stability under test conditions: No data
- Storage condition of test material: No data
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data on test animals and environmental conditions.
Test system
- Vehicle:
- other: Olive oil
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): 10, 20, 30, 40, 50, and 60% - Duration of treatment / exposure:
- 1 minute and 24 hours
- Observation period (in vivo):
- 24 hours
- Number of animals or in vitro replicates:
- 48 (8/dose group)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): In each dose group the eyes of 4 animals were rinsed for 1 minute with physiological saline, and those of the remaining 4 were not rinsed.
- Time after start of exposure: 1 minute
SCORING SYSTEM: No data
TOOL USED TO ASSESS SCORE: No data
Results and discussion
In vivo
Results
- Remarks on result:
- other: no effects observed in all concentrations, no individual scores provided
- Irritant / corrosive response data:
- At 10, 20, 30, 40, 50, or 60% no effects and no reactions were observed.
- Other effects:
- no other effects reported
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- At 10, 20, 30, 40, 50, and 60% no effects and no reactions were observed. Under the conditions of this study, 10 to 60% test substance in olive oil was not an eye irritant in rabbits.
- Executive summary:
In an eye irritation test following the method of Draize, 0.1 ml of 10, 20, 30, 40, 50, or 60% test substance, Brazilian menthol (peppermint oil), diluted in olive oil, was applied to the right eye (conjunctival sac) of rabbits (8 animals/dose group). The upper and lower lids were held closed for one minute. Afterwards, the eyes of 4 animals were rinsed for 1 minute with physiological saline and those of the remaining 4 were not rinsed. The test substance mixture was warmed at the 3 highest concentrations to keep the mixture fluid. At 10, 20, 30, 40, 50, or 60% no effects and no reactions were observed. Under the conditions of this study, 10 to 60% Brazilian menthol (peppermint oil) in olive oil was not an eye irritant in rabbits. The documentation is a summary of methods and results, individual scores are not included. Therefore, no conclusion on classification in accordance with 67/548/EEC and 1272/2008/EC can be drawn.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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