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EC number: 248-299-9 | CAS number: 27178-16-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 May - 12 Jun 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study with analytical monitoring
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 202, part 2 adopted in 1984
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 2 mg/L treatment
- Sampling method: A separate test concentration was prepared and used for testing the stability of the test substance in water. - Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: A stock solution was prepared by by mixing 1 g test substance with 1 g vehicle in 1 L of dionized water. The stock solution was diluted to the respective test concentrations.
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): MARLOWET R 40
- Concentration of vehicle in test medium (stock solution and final test solution(s) including control(s)): 2 mg/L
- Evidence of undissolved material (e.g. precipitate, surface film, etc): not stated - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain/clone: clone 5
- Source: own breeding
- Age of parental stock (mean and range, SD): < 24 hours
- Feeding during test
- Food type: green algae
- Amount: 0.5E7 cells/daphnid from day 0 to day 6; 1.0E7 cells/daphnid from day 7 to day 21
- Frequency: daily
HOUSING
- Housing medium: M4-medium (Elendt, 1990)
- Housing conditions: each test organism were kept separate in 60 mL test water - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Test temperature:
- 20 ± 1 °C
- pH:
- 7.8 - 8.6
- Dissolved oxygen:
- 94 - 107 mg/L
- Nominal and measured concentrations:
- Nominal test concentrations: 0.5, 1.0, 2.0 mg/L
Measured concentrations: 0.19, 0.39, 0.77 mg/L (geometric mean, biological active) - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, total volume, fill volume: glass beakers, 150 mL, 100 mL
- Renewal rate of test solution (frequency): after 2, 6, 7, 9, 12, 14, 16, 19 days
- No. of organisms per vessel: 1
- No. of vessels per concentration (replicates): 10
- No. of vessels per control (replicates): 10
- No. of vessels per vehicle control (replicates): 10
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: synthetic freshwater according to Elendt (M4-medium)
- Culture medium different from test medium: no
- Intervals of water quality measurement: pH-value and oxygen content of the new test solutions at day 2, 12, 16 and of the old test solutions at day 6, 14, 19.
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light and 8 hours darkness
- Light intensity: approx. 450 and 95 Lux
EFFECT PARAMETERS MEASURED: Immobility and reproduction was recorded after 2, 6, 7 9, 12, 14, 16, 19, 21 days.
VEHICLE CONTROL PERFORMED: yes - Reference substance (positive control):
- no
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 0.77 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: reproduction and survival
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 0.77 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: reproduction and survival
- Details on results:
- No significant effects were observed in up to the highest concentration tested.
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 21d long-term toxicity test with Daphnia magna revealed that DEHA does not cause adverse effects to reproduction and survival up to the saturation limit in water.
- Executive summary:
The GLP study was performed according to OECD guideline 202, part 2 using Daphnia magna as test organism. Test concentrations from 0.5 to 2 mg/L were tested using Marlowet R40 as vehicle (2 mg/L). The stability of the highest test concentration (2 mg/L) was analytically examined. A geometric mean value of 0.77 mg/L was measured. No significant effects on reproduction and survival were observed up to the highest concentration tested. Thus, the 21d-NOEC value is determined to be > 0.77 mg/L (measured concentration) and > the solubility in water, respectively.
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- Please see Section 13 below.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 0.77 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: reproduction and survival
- Key result
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 0.77 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: reproduction and survival
Referenceopen allclose all
Table 1: Results of test substance analytics
Nominal concentration [mg/L] |
Determination |
Fresh test solution |
Old test solution (2 days) |
geometric mean [mg/L] |
2.0 |
1 |
1.8 |
< 0.05 |
- |
2 |
1.8 |
0.86 |
- |
|
3 |
1.9 |
0.12 |
- |
|
mean |
1.8 |
0.33 |
0.77 |
Description of key information
No relevant studies are available for diisodecyl adipate.
A long-term toxicity study in Daphnia Magna is available for the closely related, read-across substance, bis(2-ethylhexyl) adipate (CAS 103-23-1). The GLP study was performed according to OECD guideline 202, part 2 using Daphnia magna as test organism. Test concentrations from 0.5 to 2 mg/L were tested using Marlowet R40 as vehicle (2 mg/L). The stability of the highest test concentration (2 mg/L) was analytically examined. A geometric mean value of 0.77 mg/L was measured. No significant effects on reproduction and survival were observed up to the highest concentration tested. Thus, the 21d-NOEC value is determined to be > 0.77 mg/L (measured concentration) and > the solubility in water, respectively.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.