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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 908-918-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- substance was allowed to volatize from the patch for 15min prior to application. Potentially hardly any test substance applied.
Data source
Reference
- Reference Type:
- publication
- Title:
- Submission of unpublished data by CTFA. Repeat insult patch test on amyl and Isoamyl Acetate
- Author:
- CTFA
- Year:
- 1 987
- Bibliographic source:
- cited in: Ibanez, P., Final Report on the Safety Assessment of Amyl Acetate and Isoamyl Acetate, J. Americ. Coll. Toxicol., 7(6), 705-719, 1988
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Repeat insult patch test with 197 subjects.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Reference substance 001
- Details on test material:
- no data
Constituent 1
Method
- Type of population:
- not specified
- Subjects:
- - Number of subjects exposed:
- Sex: 211 male and female subjects, a total of 197 subjects completed the study
- Other: - Controls:
- A vehicle control, 75% ethanol and 25% diethyl phthalate, was also included in the testing program.
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
- Description of patch: The test material, 0 .3 ml, was applied to a Webril patch and allowed to volatilize for 15 minutes before applying the patch to the skin site.
- Concentrations: 20% solution
- Volume applied: 0.3 ml
- Testing/scoring schedule: The sites were evaluated at 48 and 96 h after application throughout the treatment period.Following a 10-15 day nontreatment period, the subjects were given a challenge patch using the same dose and contact period as used during the induction phase of the study.
- Removal of test substance: after 24 h (the sites were evaluated and fresh patches applied three times per week for 3 weeks)
Results and discussion
- Results of examinations:
- No evidence of delayed-contact hypersensitivity was observed, and no adverse reactions were observed during the entire exposure period to amyl acetate.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.