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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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Reaction mass of 2-[[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]methyl]oxirane and 1,3-bis[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]propan-2-ol and 1-[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]-3-[4-[[4-[3-[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]-2-hydroxy-propoxy]-3,5-dimethyl-phenyl]methyl]-2,6-dimethyl-phenoxy]propan-2-ol
EC number: 941-357-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to OECD guidance but not GLP. Specific details relating to the experimental study design are not provided for assessment.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- yes
- Remarks:
- Increased study duration
- GLP compliance:
- no
- Remarks:
- This study was not conducted specifically for REACH registration initially (other regulatory purposes), however the data are considered sufficient to show no biodegradation of the substance.
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- natural water
- Details on inoculum:
- Inoculum: Surface water from Skokie, IL water district.
The proportion and nature of industrial waste in inoculum is unknown, but there is discharge from a waste treatment facility within 1 mile.
Bacterial inoculum: ca. 1E5 cfu/mL - Duration of test (contact time):
- 31 d
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
No details are available on the media composition. The test temperature was detailed as 22°C +/- 2°C, with a Final pH of 7.75. Total carbon analysis value for the test substance was determined to be 81.5%. - Reference substance:
- acetic acid, sodium salt
- Remarks:
- Sodium acetate
- Test performance:
- The results showed no biodegradation of the test substance by the end of the study.
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- ca. 0
- Sampling time:
- 31 d
- Details on results:
- The results showed no biodegradation of the test substance by the end of the study.
- Results with reference substance:
- The reference control provided reached 60% (% ThCO2) by Day 14 of the test and 75.5% (+/- 7%) by the end of the test, with a final pH value of 7.6.
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Under the conditions of the OECD 301B guideline test, no biodegradation of the test substance was observed over a 31 day testing period, using surface water as an inoculum.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to OECD guidance but not GLP. Specific details relating to the experimental study design are not provided for assessment.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- yes
- Remarks:
- Increased study duration
- GLP compliance:
- no
- Remarks:
- This study was not conducted specifically for REACH registration initially (other regulatory purposes), however the data are considered sufficient to show no biodegradation of the substance.
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- not specified
- Details on inoculum:
- An industrial inoculum was used on test (assumed to be adapted to the test substance).
The micro-organism concentrations were checked on day 0 and 20 of the test and were determined to exceed 1E7 CFU/mL per sample chamber. - Duration of test (contact time):
- 35 d
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
No details are available on the media composition. The test temperature was detailed as 22°C +/- 2°C, with a Final pH of 7.4. Total carbon analysis value for the test substance was determined to be 82%. - Reference substance:
- acetic acid, sodium salt
- Remarks:
- Sodium acetate
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 35 d
- Details on results:
- The results showed no biodegradation of the test substance by the end of the study.
- Results with reference substance:
- The reference control provided reached 60% (% ThCO2) by Day 17 of the test and 72% by the end of the test.
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Under the conditions of the OECD 301B guideline test, no biodegradation of the test substance was observed over a 35 day testing period, assumed to be using adapted industrial site inocula.
Referenceopen allclose all
Description of key information
Two ready biodegradation studies are available conducted in accordance with OECD 301B guideline. The information provided in these testing reports is generally deficient with regards to experimental method detail.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
The initial study using the substance has shown no ready biodegradation over a 31 day testing period, based on percent of maximum CO2 evolved (compared with ThCO2). The study was repeated with an extended test period, 35 days (with similar deficiencies in experimental method details). This study also showed no biodegradation of the test substance.
Together these studies show a distinct lack of biodegradation of the substance under aerobic conditions, and as such are considered acceptable to fulfil this specific information requirement.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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