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EC number: 274-778-7 | CAS number: 70693-62-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1985-02-13 - 1985-05-29
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was not performed according to GLP. The identity and purity of the test material was not specified in the study report. During the rechallenge a high incidence of skin reactions was observed in both control and test group animals after application of distilled water only.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- , several quality assurance inspections were carried out.
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- The study as conducted before the LLNA became the standard method for testing skin sensitisation.
Test material
- Reference substance name:
- Pentapotassium bis(peroxymonosulphate) bis(sulphate)
- EC Number:
- 274-778-7
- EC Name:
- Pentapotassium bis(peroxymonosulphate) bis(sulphate)
- Cas Number:
- 70693-62-8
- Molecular formula:
- H3K5O18S4
- IUPAC Name:
- pentapotassium bis((hydroperoxysulfonyl)oxidanide) hydrogen sulfate sulfate
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- not indicated
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- other: distilled water
- Concentration / amount:
- Primary induction (intradermal): 1% w/v in distilled water and in Freunds Complete adjuvant, respectively
Secondary Induction (epicoutaneous): 0.6 ml 15% w/v KMPS triple salt in distilled water
First Challenge: 0.2 ml 6% w/v KMPS triple salt in distilled water
Second Challenge: 0.2 ml 3% w/v KMPS triple salt in distilled water
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: distilled water
- Concentration / amount:
- Primary induction (intradermal): 1% w/v in distilled water and in Freunds Complete adjuvant, respectively
Secondary Induction (epicoutaneous): 0.6 ml 15% w/v KMPS triple salt in distilled water
First Challenge: 0.2 ml 6% w/v KMPS triple salt in distilled water
Second Challenge: 0.2 ml 3% w/v KMPS triple salt in distilled water
- No. of animals per dose:
- ten males, ten females,
controls: ten males, ten females - Details on study design:
- not indicated
- Challenge controls:
- not indicated
- Positive control substance(s):
- not specified
Results and discussion
- Positive control results:
- not indicated
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- positive control
- Remarks on result:
- not measured/tested
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- positive control
- Remarks on result:
- not measured/tested
- Key result
- Reading:
- other: first challenge, 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 6% w/v KMPS triple salt
- No. with + reactions:
- 9
- Total no. in group:
- 20
- Clinical observations:
- only slight or moderate patchy erythema
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: other: first challenge, 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 6% w/v KMPS triple salt. No with. + reactions: 9.0. Total no. in groups: 20.0. Clinical observations: only slight or moderate patchy erythema.
- Key result
- Reading:
- other: first challenge, 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 6% w/v KMPS triple salt
- No. with + reactions:
- 1
- Total no. in group:
- 20
- Clinical observations:
- only slight or moderate patchy erythema
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: other: first challenge, 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 6% w/v KMPS triple salt. No with. + reactions: 1.0. Total no. in groups: 20.0. Clinical observations: only slight or moderate patchy erythema.
- Key result
- Reading:
- other: first challenge, 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 6% w/v KMPS triple salt
- No. with + reactions:
- 5
- Total no. in group:
- 20
- Clinical observations:
- only slight or moderate patchy erythema
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: other: first challenge, 1st reading. . Hours after challenge: 24.0. Group: other: concurrent control. Dose level: 6% w/v KMPS triple salt. No with. + reactions: 5.0. Total no. in groups: 20.0. Clinical observations: only slight or moderate patchy erythema.
- Key result
- Reading:
- other: first challenge, 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 6% w/v KMPS triple salt
- No. with + reactions:
- 1
- Total no. in group:
- 20
- Clinical observations:
- only slight or moderate patchy erythema
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: other: first challenge, 2nd reading. . Hours after challenge: 48.0. Group: other: concurrent control. Dose level: 6% w/v KMPS triple salt. No with. + reactions: 1.0. Total no. in groups: 20.0. Clinical observations: only slight or moderate patchy erythema.
- Key result
- Reading:
- other: first challenge, 1st and 2nd reading
- Group:
- test chemical
- Dose level:
- distilled water
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- none
- Remarks on result:
- other: Reading: other: first challenge, 1st and 2nd reading. Group: other: test group. Dose level: distilled water. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: none.
- Key result
- Reading:
- other: first challenge, 1st and 2nd reading
- Group:
- negative control
- Dose level:
- distilled water
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- none
- Remarks on result:
- other: Reading: other: first challenge, 1st and 2nd reading. Group: other: concurrent control group. Dose level: distilled water. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: none.
- Key result
- Reading:
- other: rechallenge, 1st and 2nd reading
- Group:
- test chemical
- Dose level:
- 3% w/v KMPS triple salt
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- none
- Remarks on result:
- other: Reading: other: rechallenge, 1st and 2nd reading. Group: test group. Dose level: 3% w/v KMPS triple salt. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: none.
- Key result
- Reading:
- other: rechallenge, 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 3% w/v KMPS triple salt
- No. with + reactions:
- 1
- Total no. in group:
- 20
- Clinical observations:
- only slight, patchy erythema
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: other: rechallenge, 1st reading. . Hours after challenge: 24.0. Group: other: concurrent control. Dose level: 3% w/v KMPS triple salt. No with. + reactions: 1.0. Total no. in groups: 20.0. Clinical observations: only slight, patchy erythema.
- Key result
- Reading:
- other: rechallenge, 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 3% w/v KMPS triple salt
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- none
- Remarks on result:
- other: Reading: other: rechallenge, 2nd reading. . Hours after challenge: 48.0. Group: other: concurrent control. Dose level: 3% w/v KMPS triple salt. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: none.
- Key result
- Reading:
- other: rechallenge: 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- distilled water
- No. with + reactions:
- 9
- Total no. in group:
- 20
- Clinical observations:
- only slight or moderate patchy erythema
- Remarks on result:
- other: Reading: other: rechallenge: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: distilled water. No with. + reactions: 9.0. Total no. in groups: 20.0. Clinical observations: only slight or moderate patchy erythema.
- Key result
- Reading:
- other: rechallenge: 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- distilled water
- No. with + reactions:
- 1
- Total no. in group:
- 20
- Clinical observations:
- only slight or moderate patchy erythema
- Remarks on result:
- other: Reading: other: rechallenge: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: distilled water. No with. + reactions: 1.0. Total no. in groups: 20.0. Clinical observations: only slight or moderate patchy erythema.
- Key result
- Reading:
- other: rechallenge, 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- distilled water
- No. with + reactions:
- 3
- Total no. in group:
- 20
- Clinical observations:
- only slight or moderate patchy erythema
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: other: rechallenge, 1st reading. . Hours after challenge: 24.0. Group: other: concurrent control. Dose level: distilled water. No with. + reactions: 3.0. Total no. in groups: 20.0. Clinical observations: only slight or moderate patchy erythema.
- Key result
- Reading:
- other: rechallenge, 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- distilled water
- No. with + reactions:
- 2
- Total no. in group:
- 20
- Clinical observations:
- only slight or moderate patchy erythema
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: other: rechallenge, 2nd reading. . Hours after challenge: 48.0. Group: other: concurrent control. Dose level: distilled water. No with. + reactions: 2.0. Total no. in groups: 20.0. Clinical observations: only slight or moderate patchy erythema.
Any other information on results incl. tables
Primary irritation screen
Intradermal injection
Administration of 100% w/v KMPS triple salt in Freunds Complete Adjuvant proved to be impossible by injection into the dermis. Sites of intradermal injection of formulations incorporating 3% w/V KMPS triple salt in distilled water or Freunds Complete Adjuvant showed dermal changes including loss of elasticity or eschar formation which were considered to reflect substantial damage of the treated tissue. Reactions to intradermal injection of 1% w/v KMPS triple salt in either vehicle were blanching, slight or moderate erythema and or discolouration.
Occluded topical application (first phase)
Occluded topical application of 20%, 30% and 40% w/v KMPS triple salt in distilled water caused discolouration and reduced dermal pliability or eschar formation and yet treatment with 10% w/v KMPS triple salt in distilled water failed to elicit any dermal change other than pitting of the surface on one of the test sites.
Occluded topical application (second phase)
There were no irritation responses or dermal changes at the sites of occluded topical application of 3% or 6% w/v KMPS triple salt in distilled water. Formulations incorporating 12% or 20% w/v KMPS triple salt in distilled water elicit slight or moderate erythema and, in some cases, discolouration of the treated skin.
Induction
Intradermal injection
Administration of 1% w/v KMPS triple salt in distilled water or the adjuvant or of the vehicles alone or in combination, caused dermal changes such as discolouration and irritation reactions not exceeding slight erythema.
Occluded topical application
Three control males showed slight, confluent or moderate, patchy erythema 4 hours after removal of occlusive dressings which had applied distilled water to their dorsum. Contemporaenous treatment of test group animals with 15% w/v KMPS triple salt in distiled water elicited similar erythematous responses from eight guinea-pigs, but coagulated blood from injection sites disturbed during the occlusion procedure had partially obscured the dermal test sites of more than one-half of he test group animals.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The incidence of significant erythematous reations to challenge with 3% w/v KMPS triple salt in distilled water was not greater among animals previously subjected to induction procedures involving repeated administration of the test material than among animals of a comtemporaneous control group.
Under the conditions of this study, it was concluded that repeated administration of KMPS triple salt has failed to cause delayed contact hypersensitivity in guinea-pigs. - Executive summary:
Materials and methods
The potential of KMPS triple salt to cause delayed contact hypersinsitivity in guinea-pigs was assessed by the Magnusson-Kligman Maximisation Test.
The shaven dorsum of ten male and ten female Dunkin-Hartley guinea-pigs were subjected to intradermal injections of Freunds Complete Adjuvant, 1% w/v KMPS triple salt in distilled water and 1% w/v KMPS triple salt in the adjuvant on Day 1. Seven days later the same area of skin was treated by topical application of 15% w/v KMPS triple salt in distilled water and the test site was covered by an occlusive dressing for48 hours. the same induction procedures were carried out on a contemporaneous control group, except that the test material was replaced by vehicle in all doses.
On day 22 all animals were challenged by occluded application of distilled water to the left flank and 6% w/v KMPS triple salt in distilled water to the right flank. The occlusive dressings were removed on the following day and the condition of the test sites was assessed approximately 24 and 48 hours later.
The result obtained at first challenge was tested by repeating the procedure on Day 29. On this occasion the vehicle was applied to a naive site on the right flank and 3% w/v KMPS triple salt in distilled water was applied to the left flank.
Results and discussion
First challenge application of distilled water failed to elicit any erythematous responses.
Contemporaneous treatment of the opposite flank with 6% w/v KMPS triple salt in distilled water caused slight or moderate patchy erythema in five controls and nine test group animals examined 24hours after challenge and in single test and control group animals examined 48 hours after challenge.
The test sites subjected to the second challenge with the vehicle showed slight or moderate patchy erythema in three control and nine test group animals at the first examination and in two control and one test animal at the second examination.
Slight, patchy erythema affected a single control male 24 hours after second challenge application of 3% w/v KMPS triple salt in distilled water in the first reading and disappeared in the 2nd reading.
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