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Diss Factsheets
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EC number: 700-081-9 | CAS number: 635708-74-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Irritants: corrosive materials, oxidising/reducing agents, acids, and alkalis, concentrated salt solutions etc.
- Author:
- Holland G, York M
and Basketter DA. - Year:
- 1 996
- Bibliographic source:
- The Irritant Contact Dermatitis Syndrome, van der Valk PGM and Maibach HI (editors), CRC Press, Boca Raton, 55-64.
- Reference Type:
- publication
- Title:
- Toxicology of the Eye.
- Author:
- Grant WM.
- Year:
- 1 962
- Bibliographic source:
- Toxicology of the Eye, Grant WM, Charles C Thomas, Springfield.
- Reference Type:
- publication
- Title:
- Chemical Safety Data Sheets.
- Author:
- Anonymous.
- Year:
- 1 988
- Bibliographic source:
- Chemical Safety Data Sheets, volumes1-5, Royal Society of Chemistry, Cambridge.
- Reference Type:
- publication
- Title:
- Sensory irritating effects of allyl halides and a role for hydrogen bonding as a likely feature at the receptor site.
- Author:
- Nielsen GD and
Bakbo JC. - Year:
- 1 985
- Bibliographic source:
- Acta Pharmacologica et Toxicologica, 57, 106- 116.
Materials and methods
- Principles of method if other than guideline:
- Derek for windovs - Irritation of the skin
227 Allyl halide - Plausible skin irritation - GLP compliance:
- no
Test material
- Specific details on test material used for the study:
- LogP=3.546 and LogKp is predicted to be -1.158cm/hr which falls within the cut off set for skin permeability.
Results and discussion
Any other information on results incl. tables
Allyl halides are particularly irritating to eyes. Evaporation of volatile halides may reduce skin and eye irritation.
Allyl iodide is classified under EC regulations as corrosive (R34). The irritancy of allyl halides is highly dependent on the solubility in hydrophilic and lipophilic media and is sensitive to substituent types and position which influence reactivity as well as tissue penetration properties.
N.B. A structural alert for irritancy indicates some potential for this effect. Additionally, except for highly reactive corrosive substances, the skin and eye irritation potential of a chemical is very dependent on physicochemical properties which influences the concentrations at and exposure to component tissues. Skin penetration is favoured by relatively lipophilic molecules (Log P(octanol/water)= 1-4) of low molecular weight (<500). For many classes of chemicals (e.g. aliphatic amines) eye irritation is greatest for the more water soluble compounds which readily dissolve in the aqueous tear film on the cornea and conjunctiva.
Liquid substances (cf.solids) have good tissue contact and are more likely to be irritating, particularly to the skin. Highly reactive corrosive chemicals may penetrate tissue as a result of corrosive damage with a lower dependence on solubility characteristics.
Applicant's summary and conclusion
- Interpretation of results:
- other: slightly irritating
- Conclusions:
- The substance Reaction mass of of (2E)-1-chloro-6,6-dimethyl-2-Hepten-4-yne and (2Z)-1-chloro-6,6-dimethyl-2- Hepten-4-yne was predicted to have LogKp= -1.158cm/hr which falls within the cut off set for skin permeability. The substance should be classified for skin irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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