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EC number: 224-699-9 | CAS number: 4454-16-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April-May 2015
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU method B.48 (Isolated chicken eye test method for identifying occular corrosives and severe irritants)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Nickel bis(2-ethylhexanoate)
- EC Number:
- 224-699-9
- EC Name:
- Nickel bis(2-ethylhexanoate)
- Cas Number:
- 4454-16-4
- Molecular formula:
- C8H16O2.1/2Ni
- IUPAC Name:
- nickel(2+) bis(2-ethylhexanoate)
- Test material form:
- semi-solid (amorphous): gel
- Remarks:
- migrated information: paste
- Details on test material:
- Identification: Nickel 2-ethylhexanoate
Batch n° L7282
Composition : 16.02%w/w Ni
Purity ≥ 94% w/w
Impurities : Nickel acetate (EC n° 239-086-1) ≤ 6% w/w
Constituent 1
Test system
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- The test item was previously out on a gauze which was applied on the eye to cover the entire surface of the cornea. The test item was applied for 10 seconds and then rinsed from the eye with 20 mL of physiological saline at ambient temperature.
- Observation period (in vivo):
- Treated corneas are evaluated pretreatment and starting at 30, 75, 120, 180 and 240 minutes (+/- 5 min.) after the post-treatment rinse.
Results and discussion
In vitro
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Value:
- 0
- Remarks on result:
- other: maximal mean score = 0.0 corresponding to ICE class I
- Irritation parameter:
- fluorescein retention score
- Value:
- 2.3
- Remarks on result:
- other: maximal mean score = 2.3 corresponding to ICE class III
- Irritation parameter:
- corneal swelling
- Value:
- 8
- Remarks on result:
- other: maximal mean = + 8% corresponding to ICE class II
- Other effects / acceptance of results:
- Corneal opacity: maximal mean score = 0.0 corresponding to ICE class I
Fluorescein retention: maximal mean score = 2.3 corresponding to ICE class III
Corneal swelling: maximal mean = + 8% corresponding to ICE class II
Combination of the 3 endpoints: 1 x III, 1 x II, 1 x I
Any other information on results incl. tables
The combination of the 3 endpoints for the positive control, sodium hydroxide, was 3 x IV. Therefore the positive control is classified as 'Corrosive/severe irritant' as expected.
The combination of the 3 endpoints for the negative control, physiological saline, was 3 x I. Therefore the negative control as 'No category' as expected.
Applicant's summary and conclusion
- Interpretation of results:
- other: not corrosive/severe irritant
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- In accordance with Regulation EC 1272/2008, the test item does not have to be classified in category 1 'Irreversible effects on the eye'.
Nickel 2-ethylhexanaote does not have to be classified also R41 'Risk of serious damage to eyes' according to the criteria for classification, packaging and labelling of dangerous substances in compliance with the E.E.C. Directives 67/548, 2001/59 and 99/45.
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