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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 275-809-7 | CAS number: 71662-46-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer reviewed journal, read-across.
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
Further information are included in the Read-Across Justification Document. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.1 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.1 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 0.23 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 0.23 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- - Mortality of parent animals: see below
- No. of offspring produced per day per female: see below
- Body length and weight of parent animals: not reported
- Type and number of morphological abnormalities: not reported
- Type and number of behavioural abnormalities: not reported - Validity criteria fulfilled:
- yes
- Remarks:
- Based on the results of studies with similiar substances (see Read-across justification document), the result of the undelrying study is considered valid and reliable, although no specific guideline and GLP compliance are mentioned.
- Conclusions:
- The NOEC for the toxicity of di-(n-hexyl, n-octyl, n-decyl) phthalate towards Daphnia magna is reported as 0.1 mg/l and hence above the limit of water solubilty.
- Executive summary:
The underlying publication reports data for the chronic toxicity of di-(n-hexyl, n-octyl, n-decyl) phthalate towards Daphnia magna.
Daphnids were exposed to a range of concentrations ranging from 0.015 to 0.23 mg/l (mean measured) over 21 days under flow-through conditions.
No specific guideline is mentioned, but the test followed a lab internal protocol for chronic toxicity testing with invertebrates and is hence considered adequate. Survival and reproduction were monitored daily during the exposure, except for holidays, buth end points were equally sensitive.
The resulting NOEC is 0.1 mg/L.
The authors state that the exposure concentrations in this test and also in previous studies are likely to exceed the actual water solubility of the test item due to formation of micelles/microdroplets.
Staples et al. (1995) reported an aqueous solubility for di-(n-hexyl, n-octyl, n-decyl) phthalate of 0.05 mg/l.
Test organisms were found to be on the surface of the test solution in the highest concentration (=LOEC), leading to a significant effect on survival and reproduction. The reason could possibly be entrapment of daphnids by undissolved test material in form of microdroplets, as reported in former publications and reports.
Reference
Summary of survival and reproduction data
Mean measured test concentration [mg/l] | SD [mg/l] | % Survival on Day 21 (SD) | Mean offspring/female (cumulative; per living female on Day 21) |
0.23* | 0.12 | 36* (14) | 46* (9) |
0.10 | 0.05 | 76 (31) | 65 (15) |
0.053 | 0.024 | 85 (24) | 78 (12) |
0.022 | 0.004 | 100 (0) | 81 (7) |
0.015 | 0.003 | 99 (2) | 80 (7) |
Control | - | 99 (2) | 76 (6) |
*significant effect on survival and reproduction, compared to the control.
Description of key information
The NOEC for the toxicity of the read-across substance 1,2-Benzenedicarboxylic acid, di.C6-C10-alkyl esters towards Daphnia magna is reported as 0.1 mg/l and hence above the limit of water solubility. Therefore it can be concluded that no toxicity occurred up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
The NOEC for the toxicity of the read-across substance 1,2-Benzenedicarboxylic acid, di.C6-C10-alkyl esters towards Daphnia magna is reported as 0.1 mg/l and hence above the limit of water solubility.
For 1,2-Benzenedicarboxylic acid, diundecyl ester the NOEC (21d ) for reproduction and survival in Daphnia magna was reported as 0.059 mg /L at the highest concentration tested. Several other chronic invertebrate data is available for this substance, all showing no effects in the range of water solubility. The 21d-NOEC stated for 1,2-Benzenedicarboxylic acid, dihexyl ester is 0.084 mg/l (Rhodes et al., 1995). The same observations were made for 1,2-Benzenedicarboxylic acid, dioctyl ester in Daphnia with a reported 21d-NOEC of 0.32 mg/L.
All values are well above the level of water solubility (see Staples et al., 1997). In general, effects were only observed, if solvents were used and the limit of water solubility was exceeded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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