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EC number: 200-858-8 | CAS number: 75-29-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
Short description of key information:
In accordance with column 2 of REACH Annex VIII, the screening for reproductive/developmental toxicity study (required in section 8.7.1) does not need to be conducted as a pre-natal developmental toxicity study in rat is available.
Developmental toxicity is being addressed with a Testing Proposal for an OECD TG 443 study.
Effects on developmental toxicity
Description of key information
A GLP prenatal development toxicity study on isopropyl chloride (IPC) in rats conducted according to OECD guideline 414 indicated that the inhalational NOAEC for developmental toxicity was 6.67 mg/L (6670 mg/m^3), the highest dose administered. A NOAEC for maternal toxicity was not identified by the study author; however, a review of the data indicate that a NOAEC of 1.43 mg/L (1430 mg/m^3) can be considered for maternal effects.
Effect on developmental toxicity: via inhalation route
- Dose descriptor:
- NOAEC
- 6 670 mg/m³
Additional information
The effect of isopropyl chloride (IPC) on embryofetal development was evaluated in a GLP-compliant prenatal development toxicity study that was conducted according to OECD test guideline 414 (LPT Laboratory, 1992). IPC was administered by whole body inhalation to timed-pregnant Sprague-Dawley rats at dose concentrations of 0 (sham exposed), 0.61, 1.43, 2.66, or 6.67 mg/L (actual concentrations) for 6 hours/day, from gestational days 6 through 15. There were no mortalities reported. There were no maternal findings reported at the 0.61 and 1.43 mg/L dose levels. There were no changes in maternal body weight or food and drinking water consumption reported. Gross macroscopic inspection showed dark-red foci in the lungs of 2 of 20 dams in approximately 5% to 10% of the pulmonary tissue at the 2.66 mg/L dose concentration. At the 6.67 mg/L dose concentration, dark red, partly indurated foci in the lungs were reported in 9 out of 20 dams. These lesions occupied approximately 5% to 50% of the pulmonary tissue. Multiple beige foci also were detected in 8 of 20 dams. There were no discernable effects on embryotoxicity or fetotoxicity parameters at any dose level tested. At the highest IPC concentration, an increase in fetal variations consisting of slightly delayed ossification of the skull and vertebrae was reported. While this increase could be explained by maternal toxicity and/or biological variability, a relationship to the test article could not be excluded. It was concluded that there were no teratogenic effects observed. Based on these findings, the NOAEC for developmental toxicity was considered to be 6.67 mg/L (6670 mg/m3), the highest dose administered. While the study author did not identify a NOAEC for maternal toxicity, a review of the data indicates that a NOAEC of 1.43 mg/L (1430 mg/m3) can be considered for maternal toxicity.
Justification for classification or non-classification
The developmental study indicated that the submission substance does not affect the development of the offspring. However, no information is available on reproductive toxicity. As a result, data is lacking for classification according to Regulation (EC) No 1272/2008, Annex I section 3.7.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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